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Am J Physiol Regul Integr Comp Physiol 275: R1600-R1604, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 5, R1600-R1604, November 1998

Gender difference in age-related changes in muscle sympathetic nerve activity in healthy subjects

Toshiyoshi Matsukawa1, Yoshiki Sugiyama2, Takemasa Watanabe3, Fumio Kobayashi2, and Tadaaki Mano1

1 Division of Higher Nervous Control, Department of Autonomic Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601; 2 Department of Hygiene, Aichi Medical University, Aichi 480-1103; and 3 Department of Hygiene and Public Health, Osaka Medical College, Osaka 569-8686, Japan

Muscle sympathetic nerve activity (MSNA) was measured directly along with blood pressure at rest in 69 healthy women (20-79 yr old) and 76 age-matched healthy men (16-80 yr old). All were nonobese and normotensive. In the women and men the MSNA was positively correlated with age (women: y = 0.788x - 5.418, r = 0.846, P < 0.0001; men: y = 0.452x + 12.565, r = 0.751, P < 0.0001). The regression intercept of y was significantly lower (P < 0.0001) in the women than in the men, and the regression slope was significantly steeper (P < 0.0001) in the women. The MSNA was lower in women than in men among those <30 (P = 0.0012), 30-39 (P = 0.0126), and 40-49 yr old (P = 0.0462) but was similar in women and men among those 50-59 (P = 0.1911, NS) and >= 60 yr old (P = 0.1739, NS). The results suggest that MSNA increases with age in women and men and that the activity is markedly lower in young women than in men but is markedly accelerated with age.

aging; men; menopause; women


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