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Am J Physiol Regul Integr Comp Physiol 275: R937-R941, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 4, R937-R941, October 1998

Role of nitric oxide in systemic vasopressin-induced hypothermia

Alexandre A. Steiner1, Evelin C. Carnio2, José Antunes-Rodrigues3, and Luiz G. S. Branco1

1 Faculdade de Odontologia de Ribeirão Preto, 2 Escola de Enfermagem de Ribeirão Preto, and 3 Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14040-904 Ribeirão Preto, São Paulo, Brazil

It has been reported that arginine vasopressin (AVP) plays a thermoregulatory action, but very little is known about the mechanisms involved. In the present study, we tested the hypothesis that nitric oxide (NO) plays a role in systemic AVP-induced hypothermia. Rectal temperature was measured before and after AVP, AVP blocker, or NG-nitro-L-arginine methyl ester (L-NAME; NO synthase inhibitor) injection. Control animals received saline injections of the same volume. The basal body temperature (Tb) measured in control animals was 36.53 ± 0.08°C. We observed a significant (P < 0.05) reduction in Tb to 35.44 ± 0.19°C after intravenous injection of AVP (2 µg/kg) and to 35.74 ± 0.10°C after intravenous injection of L-NAME (30 mg/kg). The systemic injection of the AVP blocker [beta -mercapto-beta ,beta -cyclopentamethylenepropionyl1,O-Et-Tyr2,Val4,Arg8]vasopressin (10 µg/kg) caused a significant increase in Tb to 37.33 ± 0.23°C, indicating that AVP plays a tonic role by reducing Tb. When the treatments with AVP and L-NAME were combined, systemically injected L-NAME blunted AVP-induced hypothermia. To assess the role of central thermoregulatory mechanisms, a smaller dose of L-NAME (1 mg/kg) was injected into the third cerebral ventricle. Intracerebroventricular injection of L-NAME caused an increase in Tb, but when intracerebroventricular L-NAME was combined with systemic AVP injection (2 µg/kg), no change in Tb was observed. The data indicate that central NO plays a major role mediating systemic AVP-induced hypothermia.

endothelium-derived relaxing factor; temperature; nitric oxide synthase; arginine vasopressin


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