| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; 2 Department of Medicine, Georgetown University, Washington, District of Columbia 20007; and 3 Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
The distribution and chemical phenotypes of hindbrain neurons that are activated in rats after food ingestion were examined. Rats were anesthetized and perfused with fixative 30 min after the end of 1-h meals of an unrestricted or rationed amount of food, or after no meal. Brain sections were processed for localization of the immediate-early gene product c-Fos, a marker of stimulus-induced neural activation. Hindbrain c-Fos expression was low in rats that ate a rationed meal or no meal. Conversely, c-Fos was prominent in the medial nucleus of the solitary tract (NST) and area postrema in rats that ate to satiety. There was a significant positive correlation between postmortem weight of gastric contents and the proportion of NST catecholaminergic neurons expressing c-Fos. Cells in the ventrolateral medulla (VLM) were not activated in rats after food ingestion, in contrast with previous findings that stimulation of gastric vagal afferents with anorexigenic doses of cholecystokinin activates c-Fos expression in both NST and VLM catecholaminergic cells. These findings indicate that anatomically distinct subsets of hindbrain catecholaminergic neurons are activated in rats after food ingestion and that activation of these cells is quantitatively related to the magnitude of feeding-induced gastric distension.
feeding behavior; gastric distension; catecholamines; nucleus of the solitary tract
This article has been cited by other articles:
|
|
 |
|
  C. M. Kotz, M. A. Mullett, and C. Wang Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R359 - R366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zheng, L. M. Patterson, C. B. Phifer, and H.-R. Berthoud Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R247 - R258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Eckel, T. A. Houpt, and N. Geary Estradiol treatment increases CCK-induced c-Fos expression in the brains of ovariectomized rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1378 - R1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Eckel and N. Geary Estradiol treatment increases feeding-induced c-Fos expression in the brains of ovariectomized rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R738 - R746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Emond, G. J. Schwartz, and T. H. Moran Meal-related stimuli differentially induce c-Fos activation in the nucleus of the solitary tract Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1315 - R1321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Guo, K. N. Browning, R. C. Rogers, and R. A. Travagli Catecholaminergic neurons in rat dorsal motor nucleus of vagus project selectively to gastric corpus Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G361 - G367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yang, K. Kawakubo, H. Wong, G. Ohning, J. Walsh, and Y. Tache Peripheral PYY inhibits intracisternal TRH-induced gastric acid secretion by acting in the brain Am J Physiol Gastrointest Liver Physiol, September 1, 2000; 279(3): G575 - G581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Bae, J. L. Stamper, E. C. Heydorn, I. Zucker, and J. Dark Role of area postrema in control of torpor in Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R591 - R598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Covasa, R. C. Ritter, and G. A. Burns Reduction of food intake by intestinal macronutrient infusion is not reversed by NMDA receptor blockade Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R345 - R351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rinaman Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1999; 277(2): R582 - R590. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
