| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratoire des Maladies Métaboliques et des Micronutriments, Institut National de la Recherche Agronomique de Clermont-Ferrand/Theix, 63122 Saint-Genès-Champanelle, France
Quercetin is one of the most widely distributed flavonoids present in fruits and vegetables. The present experiments were performed on rats adapted for 3 wk to a semipurified diet supplemented with 0.2% quercetin. The major part of the circulating metabolites of quercetin (91.5%) are glucurono-sulfo conjugates of isorhamnetin (3'-O-methyl quercetin; 89.1 ± 2.1 µM) and of quercetin (14.7 ± 1.7 µM); the minor part (8.5%) is constituted by glucuronides of quercetin and its methoxylated forms (9.6 ± 2.3 µM). Conjugated dienes formation, resulting from Cu2+-catalyzed oxidation of rat very low density lipoproteins + low density lipoproteins (LDL), was effectively inhibited in vitro by conjugated metabolites of quercetin. These metabolites appeared to be four times more potent than trolox in inhibiting LDL oxidation. Moreover, the plasma from rats adapted to a diet containing 0.2% quercetin exhibited a total antioxidant status markedly higher than that of control rats (+60%). This study shows that ubiquitous quercetin is conjugated in vivo, yielding metabolites that exhibit antioxidant properties. Thus the health benefits of flavonoids in foods can be due to the antioxidant properties of their metabolites.
rat; conjugated metabolites; glucuronidation; sulfation; low-density lipoprotein oxidation
This article has been cited by other articles:
|
|
 |
|
  M. Schuier, H. Sies, B. Illek, and H. Fischer Cocoa-Related Flavonoids Inhibit CFTR-Mediated Chloride Transport across T84 Human Colon Epithelia J. Nutr., October 1, 2005; 135(10): 2320 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Benito, S. Buxaderas, and M. T. Mitjavila Flavonoid metabolites and susceptibility of rat lipoproteins to oxidation Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2819 - H2824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Crespy, C. Morand, C. Besson, N. Cotelle, H. Vezin, C. Demigne, and C. Remesy The splanchnic metabolism of flavonoids highly differed according to the nature of the compound Am J Physiol Gastrointest Liver Physiol, June 1, 2003; 284(6): G980 - G988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. A. Sesink, I. C. W. Arts, M. Faassen-Peters, and P. C.H. Hollman Intestinal Uptake of Quercetin-3-Glucoside in Rats Involves Hydrolysis by Lactase Phlorizin Hydrolase J. Nutr., March 1, 2003; 133(3): 773 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J O'Byrne, S. Devaraj, S. M Grundy, and I. Jialal Comparison of the antioxidant effects of Concord grape juice flavonoids {alpha}-tocopherol on markers of oxidative stress in healthy adults Am. J. Clinical Nutrition, December 1, 2002; 76(6): 1367 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Perez-Vizcaino, M. Ibarra, A. L. Cogolludo, J. Duarte, F. Zaragoza-Arnaez, L. Moreno, G. Lopez-Lopez, and J. Tamargo Endothelium-Independent Vasodilator Effects of the Flavonoid Quercetin and Its Methylated Metabolites in Rat Conductance and Resistance Arteries J. Pharmacol. Exp. Ther., July 1, 2002; 302(1): 66 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Crespy, O. Aprikian, C. Morand, C. Besson, C. Manach, C. Demigne, and C. Remesy Bioavailability of Phloretin and Phloridzin in Rats J. Nutr., December 1, 2001; 131(12): 3227 - 3230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Crespy, C. Morand, C. Besson, C. Manach, C. Demigne, and C. Remesy Comparison of the Intestinal Absorption of Quercetin, Phloretin and Their Glucosides in Rats J. Nutr., August 1, 2001; 131(8): 2109 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Koga and M. Meydani Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells Am. J. Clinical Nutrition, May 1, 2001; 73(5): 941 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Felgines, O. Texier, C. Morand, C. Manach, A. Scalbert, F. Regerat, and C. Remesy Bioavailability of the flavanone naringenin and its glycosides in rats Am J Physiol Gastrointest Liver Physiol, December 1, 2000; 279(6): G1148 - G1154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Middleton Jr., C. Kandaswami, and T. C. Theoharides The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer Pharmacol. Rev., December 1, 2000; 52(4): 673 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yang, S. A. Lamprecht, Y. Liu, H. Shinozaki, K. Fan, D. Leung, H. Newmark, V. E. Steele, G. J. Kelloff, and M. Lipkin Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon Carcinogenesis, September 1, 2000; 21(9): 1655 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Olthof, P. C. H. Hollman, T. B. Vree, and M. B. Katan Bioavailabilities of Quercetin-3-Glucoside and Quercetin-4'-Glucoside Do Not Differ in Humans J. Nutr., May 1, 2000; 130(5): 1200 - 1203. [Abstract] [Full Text]
|
|
|
|
|
|
V. Crespy, C. Morand, C. Manach, C. Besson, C. Demigne, and C. Remesy Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen Am J Physiol Gastrointest Liver Physiol, July 1, 1999; 277(1): G120 - G126. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
