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Am J Physiol Regul Integr Comp Physiol 274: R864-R867, 1998;
0363-6119/98 $5.00
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Vol. 274, Issue 3, R864-R867, March 1998

RAPID COMMUNICATION
Thyroid hormone-induced upregulation of Na+ channels and Na+-K+ pumps: implications for contractility

A. P. Harrison and T. Clausen

Department of Physiology, University of Aarhus, 8000 Århus C, Denmark

We have previously observed in rat soleus muscle that endurance is a function of the ratio between the concentration of Na+ channels and Na+-K+ pumps [Harrison, A. P., O. B. Nielsen, and T. Clausen. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R1402-R1408, 1997]. In this study we explore this relationship further by comparing the changes in Na+ channel and Na+-K+ pump concentrations induced by injections of 3,5,3'-triiodothyronine (T3) with endurance. T3 induced upregulation of the concentration of Na+ channels and Na+-K+ pumps, which was associated with a progressive loss of contractile endurance. The increase in Na+ channels preceded that of the Na+-K+ pumps and amounted to 49 and 52% (both P < 0.01) after 48 and 72 h of T3 treatment, respectively. Concomitantly, during 90-Hz stimulation, the initial rate of force decline increased by 42 and 45% after 48 and 72 h of T3 treatment, respectively (both P < 0.001). These observations are important for an understanding of the fatigue associated with hyperthyroidism and add further support to the hypothesis that muscle endurance depends on the leak-to-pump ratio for Na+.

[3H]ouabain binding; [3H]saxitoxin binding


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