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Am J Physiol Regul Integr Comp Physiol 274: R735-R740, 1998;
0363-6119/98 $5.00
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Vol. 274, Issue 3, R735-R740, March 1998

Brain type I but not type II IL-1 receptors mediate the effects of IL-1beta on behavior in mice

Sandrine Cremona1, Emmanuelle Goujon1, Keith W. Kelley2, Robert Dantzer1, and Patricia Parnet1

1 Institut National de la Santé et de la Recherche Médicale U394, Neurobiologie Intégrative, 33077 Bordeaux Cedex, France; and 2 Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801

In the immune system, interleukin (IL)-1beta effects are mediated by the type I IL-1 receptors (IL-1RI), whereas the type II IL-1 receptors (IL-1RII) act as inhibitory receptors. IL-1RI and IL-1RII are also present in the brain. To study their functionality in the brain, mice were centrally treated with neutralizing monoclonal antibody (MAb) directed against IL-1RI (35F5, 1 µg) or against IL-1RII (4E2, 2 µg) and were centrally injected with recombinant rat IL-1beta at a dose (2 ng) that decreased social exploration. Only 35F5 was effective in abrogating the behavioral effect of IL-1beta . Moreover, 4E2 (1 µg icv) did not potentiate the behavioral response to a subthreshold dose of IL-1beta (1 ng icv). To examine the ability of brain IL-1RI to mediate the effects of endogenous IL-1beta , mice were centrally treated with 35F5 (4 µg) and peripherally injected with IL-1beta (1 µg). Like IL-1 receptor antagonist (4 µg icv), 35F5 abrogated the effects of IL-1beta . These results suggest that brain IL-1RI mediates the behavioral effects of IL-1beta in mice.

antibodies; social exploration; mouse


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