AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 274: R564-R570, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mattson, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mattson, D. L.
Vol. 274, Issue 2, R564-R570, February 1998

SPECIAL COMMUNICATION
Long-term measurement of arterial blood pressure in conscious mice

David L. Mattson

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226

This study describes a technique for the direct daily measurement of arterial blood pressure, sampling of arterial blood, and continuous intravenous infusion in free-moving, conscious, Swiss-Webster mice. Catheters were chronically implanted in the femoral artery and vein, tunneled subcutaneously, exteriorized at the back of the neck in a lightweight tethering spring, and attached to a swivel device at the top of the cage. Time-control experiments (n = 8) demonstrated stable values of mean arterial pressure (MAP, 116 ± 1 mmHg) and heart rate (HR, 627 ± 21 beats/min) for up to 35 days after catheter implantation. It was further observed that restraining mice (n = 7) increased MAP by 10 ± 3 mmHg and HR by 78 ± 8 beats/min from the values observed under free-moving conditions. To demonstrate the chronic use of the venous catheter, intravenous infusion of NG-nitro-L-arginine methyl ester (L-NAME, 8.6 mg · kg-1 · day-1, n = 6) for 5 days significantly increased MAP from 117 ± 4 to 131 ± 4 mmHg without altering HR. In a final group of mice (n = 5), oral L-arginine (2% in drinking water) increased plasma arginine concentration from 90 ± 7 to 131 ± 17 µM and prevented L-NAME hypertension. These experiments illustrate the feasibility of long-term intravenous infusion, direct arterial blood pressure measurements, and arterial blood sampling in conscious mice.

hypertension; nitric oxide; arginine


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Just and W. J. Arendshorst
A novel mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1489 - F1500.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Dickinson, K. Moritz, E. M. Wintour, D. W. Walker, and M. M. Kett
A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: response to dietary salt load
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1093 - F1098.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. M. Fitzgerald, B. K. Kemp-Harper, H. C. Parkington, G. A. Head, and R. G. Evans
Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R707 - R713.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Dickinson, D. W. Walker, E. M. Wintour, and K. Moritz
Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R453 - R461.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. E. Whitesall, J. B. Hoff, A. P. Vollmer, and L. G. D'Alecy
Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2408 - H2415.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Masuki, M. Takeoka, S.'I. Taniguchi, and H. Nose
Enhanced baroreflex sensitivity in free-moving calponin knockout mice
Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H939 - H946.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ehmke
Mouse gene targeting in cardiovascular physiology
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R28 - R30.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. A. Janssen and J. F. M. Smits
Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1545 - R1564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. N. Lorenz
A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1565 - R1582.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Janssen, J. Debets, P. Leenders, and J. Smits
Chronic measurement of cardiac output in conscious mice
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R928 - R935.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. M. Fitzgerald, J. R. Henegar, M. W. Brands, L. K. Henegar, and J. E. Hall
Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R547 - R552.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
G. M. BUTZ and R. L. DAVISSON
Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool
Physiol Genomics, March 8, 2001; 5(2): 89 - 97.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Kramer, A. Aragones, and T. G. Waldrop
Reflex cardiovascular responses originating in exercising muscles of mice
J Appl Physiol, February 1, 2001; 90(2): 579 - 585.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Just, J. Faulhaber, and H. Ehmke
Autonomic cardiovascular control in conscious mice
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2214 - R2221.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. A. Mills, D. A. Huetteman, B. P. Brockway, L. M. Zwiers, A. J. M. Gelsema, R. S. Schwartz, and K. Kramer
A new method for measurement of blood pressure, heart rate, and activity in the mouse by radiotelemetry
J Appl Physiol, May 1, 2000; 88(5): 1537 - 1544.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. A. Janssen, P. J. A. Leenders, and J. F. M. Smits
Short-term and long-term blood pressure and heart rate variability in the mouse
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R215 - R225.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Li, S. H. Sur, R. E. Mistlberger, and M. Morris
Circadian blood pressure and heart rate rhythms in mice
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R500 - R504.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online