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Am J Physiol Regul Integr Comp Physiol 273: R1407-R1413, 1997;
0363-6119/97 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 273, Issue 4 1407-R1413, Copyright © 1997 by American Physiological Society

ARTICLES

Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men

T. Mulligan, A. Iranmanesh, M. L. Johnson, M. Straume and J. D. Veldhuis
Department of Internal Medicine, Hunter Holmes McGuire Veterans Affairs Medical Center, Medical College of Virginia, Richmond 23249, USA.

To discern the effect of aging on coordinate luteinizing hormone (LH) and testosterone secretion, we sampled healthy older men (age 62-74 yr, n = 11) and young controls (age 21-34 yr, n = 13) every 2.5 min overnight. Deconvolution analysis and cross-correlation were used to relate serum LH concentrations to calculated testosterone secretion rates (feed-forward stimulation), as well as serum testosterone concentrations to computed LH secretion rates (feedback inhibition). Despite statistically similar mean serum LH and testosterone concentrations in the young and older men, older individuals had diminished feed-forward stimulation of LH concentrations on calculated testosterone secretion rates, as well as delayed feedback inhibition of testosterone concentrations on computed LH secretion rates.


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