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AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 5 1613-R1619, Copyright © 1997 by American Physiological Society
ARTICLES |
M. Boulton, M. Flessner, D. Armstrong, J. Hay and M. Johnston
Trauma Research Program, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
The plasma recovery of an intraventricularly administered protein was compared before and after lymph diversion/ligation in the same conscious sheep to determine the relative roles of arachnoid villi and lymphatics in the clearance of a cerebral spinal fluid tracer. 125I-human serum albumin was injected into both lateral ventricles, and venous blood was sampled. One day later, multiple cervical vessels and the thoracic duct were cannulated for lymph collection. Uncannulated vessels were ligated. The experiment was repeated with 131I-human serum albumin as the tracer. Before lymph diversion/ligation, the time-averaged tracer transport into the plasma was 6.4 +/- 1.0%/h, with an average 6-h plasma recovery of 38.2 +/- 5.7% (percentage of injected dose). After lymph diversion/ligation, the values dropped to 2.9 +/- 0.5%/h and 17.7 +/- 2.7%, respectively. The collected lymph contained 8.7 +/- 2.6% of the tracer. No significant differences were observed in sham-operated animals. In conclusion, extracranial lymphatic vessels in sheep transport approximately one-half of the protein tracer from the cerebral spinal fluid compartment into plasma.
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J. B. Dickstein, H. Moldofsky, F. A. Lue, and J. B. Hay Intracerebroventricular injection of TNF-alpha promotes sleep and is recovered in cervical lymph Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1999; 276(4): R1018 - R1022. [Abstract] [Full Text] [PDF]
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M. Boulton, M. Flessner, D. Armstrong, R. Mohamed, J. Hay, and M. Johnston Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R818 - R823. [Abstract] [Full Text] [PDF]
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M. Boulton, M. Flessner, D. Armstrong, J. Hay, and M. Johnston Determination of volumetric cerebrospinal fluid absorption into extracranial lymphatics in sheep Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R88 - R96. [Abstract] [Full Text] [PDF]
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