AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 4 1162-R1169, Copyright © 1997 by American Physiological Society

ARTICLES

Role of nitric oxide in the arterial pressure and renal adaptations to long-term changes in sodium intake

R. D. Manning Jr, L. Hu and J. F. Reckelhoff
Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson 39216-4505, USA.

The goals of this study were to determine whether long-term nitric oxide (NO) synthesis inhibition in dogs results in an increase in the sodium sensitivity of arterial pressure and whether changes in plasma renin activity or the plasma concentrations of arginine vasopressin (AVP) and aldosterone play an important role in this hypertension. Studies were conducted in a control group and groups that received NO inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME) at 10 or 25 microg x kg(-1) x min(-1). Each group was challenged with normal, low, and high sodium intake for periods of 5 days each. Urinary nitrate + nitrite excretion (UNOx) more than doubled in the control group during high sodium intake. In both L-NAME groups, UNOx decreased significantly, there was a hypertensive shift in the relation between urinary sodium excretion and arterial pressure, and urinary sodium excretion remained normal even in the high-sodium intake period. L-NAME infusion did not change the sodium sensitivity of arterial pressure or plasma renin activity, plasma aldosterone, and plasma AVP. In conclusion, the data suggest that, in dogs, increases in NO synthesis are not necessary to excrete a chronic sodium load, and decreases in NO do not increase the sodium sensitivity of arterial pressure.

This article has been cited by other articles:

				E. SEELIGER, P. B. PERSSON, W. BOEMKE, G. MOLLENHAUER, B. NAFZ, and H. W. REINHARDT Low-Dose Nitric Oxide Inhibition Produces a Negative Sodium Balance in Conscious Dogs J. Am. Soc. Nephrol., June 1, 2001; 12(6): 1128 - 1136. [Abstract] [Full Text]

				M. Mac Laughlin, M. C. Damasco, P. Igarreta, and C. Amorena In vitro and in vivo evaluation of proximal tubular acidification in aging rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2001; 280(6): R1627 - R1631. [Abstract] [Full Text] [PDF]

				C. Loichot, C. Cazaubon, M. Grima, W. De Jong, D. Nisato, J.-L. Imbs, and M. Barthelmebs Vasopressin Does not Effect Hypertension Caused by Long-Term Nitric Oxide Inhibition Hypertension, February 1, 2000; 35(2): 602 - 608. [Abstract] [Full Text] [PDF]

				A. Kurtz and C. Wagner Role of nitric oxide in the control of renin secretion Am J Physiol Renal Physiol, December 1, 1998; 275(6): F849 - F862. [Abstract] [Full Text] [PDF]

				N. Miyata, A. P. Zou, D. L. Mattson, and A. W. Cowley Jr. Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1667 - R1673. [Abstract] [Full Text] [PDF]