AJP - Regu AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 272: R862-R868, 1997;
0363-6119/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Luheshi, G. N.
Right arrow Articles by Rothwell, N. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Luheshi, G. N.
Right arrow Articles by Rothwell, N. J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 3 862-R868, Copyright © 1997 by American Physiological Society

ARTICLES

Febrile response to tissue inflammation involves both peripheral and brain IL-1 and TNF-alpha in the rat

G. N. Luheshi, A. Stefferl, A. V. Turnbull, M. J. Dascombe, S. Brouwer, S. J. Hopkins and N. J. Rothwell
School of Biological Sciences, University of Manchester, United Kingdom.

We investigated the role and interaction between tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in the development of fever and their involvement in brain and systemic pathways in response to localized tissue inflammation caused by injection of turpentine (TPS) in the rat. Intramuscular injection of 10 microl TPS caused significant increases in body temperature, of up to 2 degrees C, compared with saline-treated animals. Fevers were maximal 7-8 h after injection and were preceded by significant increases in plasma bioactive IL-6. No changes in circulating bioactive IL-1 or TNF-alpha were detected. Systemic injection of IL-1 receptor antagonist (IL-1ra, 2 mg/kg i.p.) or anti-TNF-alpha antiserum (0.4 ml i.v.) almost completely abolished the febrile responses to TPS over 8 h and markedly inhibited the rise in plasma IL-6 bioactivity measured 6 h after TPS. To test the involvement of brain cytokines, anti-TNF-alpha antiserum and IL-1ra were injected intracerebroventricularly. Injections of anti-TNF-alpha antiserum (3 microl/rat i.c.v.) or IL-1ra (400 microg/kg i.c.v.) significantly (P < 0.01 and P < 0.05, respectively) inhibited fever induced by TPS. These data suggest that both localized peripheral and brain IL-1 and TNF-alpha are involved directly in the pyrogenic response to inflammation. The results indicate that, in the periphery, IL-1 and TNF-alpha cause increased production of IL-6, the most likely candidate as a circulating endogenous pyrogen.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
A. Aguilar-Valles, S. Poole, Y. Mistry, S. Williams, and G. N. Luheshi
Attenuated fever in rats during late pregnancy is linked to suppressed interleukin-6 production after localized inflammation with turpentine
J. Physiol., August 15, 2007; 583(1): 391 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. L. Lim, G. Wilson, L. Brown, J. S. Coombes, and L. T. Mackinnon
Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R186 - R194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M.-E. Fortier, S. Kent, H. Ashdown, S. Poole, P. Boksa, and G. N. Luheshi
The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R759 - R766.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Miyoshi, K. Nagata, T. Imoto, O. Goto, A. Ishida, and T. Watanabe
ANG II is involved in the LPS-induced production of proinflammatory cytokines in dehydrated rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1092 - R1097.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Boutin, R. A. LeFeuvre, R. Horai, M. Asano, Y. Iwakura, and N. J. Rothwell
Role of IL-1{alpha} and IL-1{beta} in Ischemic Brain Damage
J. Neurosci., August 1, 2001; 21(15): 5528 - 5534.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. D. Josephs, C. C. Solorzano, M. Taylor, J. J. Rosenberg, D. Topping, A. Abouhamze, S. L. D. Mackay, E. Hirsch, D. Hirsh, M. Labow, et al.
Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2000; 278(4): R824 - R830.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Cartmell, T. Southgate, G. S. Rees, M. G. Castro, P. R. Lowenstein, and G. N. Luheshi
Interleukin-1 Mediates a Rapid Inflammatory Response After Injection of Adenoviral Vectors into the Brain
J. Neurosci., February 15, 1999; 19(4): 1517 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Philippe, P. Gegout-Pottie, C. Guingamp, K. Bordji, B. Terlain, P. Netter, and P. Gillet
Relations between functional, inflammatory, and degenerative parameters during adjuvant arthritis in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1550 - R1556.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online