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Am J Physiol Regul Integr Comp Physiol 272: R710-R717, 1997;
0363-6119/97 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 272, Issue 2 710-R717, Copyright © 1997 by American Physiological Society

ARTICLES

Purification, structural characterization, and cardiovascular activity of cod bradykinins

B. Platzack and J. M. Conlon
Department of Zoophysiology, University of Goteborg, Sweden.

Incubation of plasma from the Atlantic cod Gadus morhua with trypsin generated two peptides identified as [Trp5,Leu8]bradykinin (cod BK) and [Arg0,Trp5,Leu8]bradykinin (cod [Arg0]BK). Bolus intraarterial injections of synthetic cod [Arg0]BK (0.1-10 nmol/kg) into conscious cod produced an immediate increase in ventral aortic pressure that was of relatively short duration (<5 min) and an increase in heart rate. Cod [Arg0]BK was approximately 10 times more potent than cod BK, and the maximal pressor response produced by the peptide was significantly (P < 0.05) greater. Bolus intra-arterial injections of either mammalian BK or cod des-Arg9,[Arg0]BK, in doses up to 100 nmol/kg, had no effect on pressure or heart rate. The data indicate that the ligand binding properties of the BK receptors in cod are different from those of the mammalian B1- and B2-receptor subtypes. The pressor response to 1 nmol/kg cod [Arg0]BK was reduced (by 51 +/- 6%; P < 0.05) in prasozin-treated fish, whereas in enalapril-treated fish, the response to the peptide was enhanced (by 42 +/- 12%; P < 0.05). The data indicate an involvement of catecholamines but not an activation of the renin-angiotensin system in mediating the vasopressor action of BK in the cod.


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