| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 6 1550-R1560, Copyright © 1996 by American Physiological Society
ARTICLES |
R. K. Porter, A. J. Hulbert and M. D. Brand
Department of Biochemistry, University of Cambridge, United Kingdom.
We investigated why liver mitochondria from small mammals are leakier to protons than those from larger mammals. Sixty-nine percent (+/-23%) of the proton leak differences appeared to relate to membrane area (less inner membrane surface area in larger animals); any residual differences must reflect differences in membrane properties. There were differences in phospholipid fatty acid composition; unsaturation index, monounsaturates, palmitate (16:0), stearate (18:0), docosahexaenoate [22:6(n-3)], and the 22:6(n-3)/22:5(n-3) ratio all correlated with body mass. Proton flux per square centimeter did not correlate significantly with body mass or, in general, with phospholipid fatty acid composition, suggesting little role for fatty acid composition in determining proton leak in mammals of different body mass. However, unsaturation index and n-3 polyunsaturated fatty acid content correlated significantly with proton leak per milligram phospholipid when literature data from reptiles and rats in different thyroid states were included, giving some support to suggestions of a general role for phospholipid fatty acid composition in determining mitochondrial proton leak.
This article has been cited by other articles:
|
|
 |
|
  C. Romestaing, M.-A. Piquet, D. Letexier, B. Rey, A. Mourier, S. Servais, M. Belouze, V. Rouleau, M. Dautresme, I. Ollivier, et al. Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E110 - E119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Arvier, L. Lagoutte, G. Johnson, J.-F. Dumas, B. Sion, G. Grizard, Y. Malthiery, G. Simard, and P. Ritz Adenine nucleotide translocator promotes oxidative phosphorylation and mild uncoupling in mitochondria after dexamethasone treatment Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1320 - E1324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. L. Brown, A. R. Gerson, and J. F. Staples Mitochondrial metabolism during daily torpor in the dwarf Siberian hamster: role of active regulated changes and passive thermal effects Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1833 - R1845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Hulbert, R. Pamplona, R. Buffenstein, and W. A. Buttemer Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals Physiol Rev, October 1, 2007; 87(4): 1175 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ocloo, I. G. Shabalina, J. Nedergaard, and M. D. Brand Cold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1 Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1086 - R1093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hagopian, M.-E. Harper, J. J. Ram, S. J. Humble, R. Weindruch, and J. J. Ramsey Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria Am J Physiol Endocrinol Metab, April 1, 2005; 288(4): E674 - E684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Turner, K. L. Haga, A. J. Hulbert, and P. L. Else Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R301 - R310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Chamberlin Control of oxidative phosphorylation during insect metamorphosis Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R314 - R321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Ramsey, K. Hagopian, T. M. Kenny, E. K. Koomson, L. Bevilacqua, R. Weindruch, and M.-E. Harper Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E31 - E40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Hulbert, S. Faulks, W. A. Buttemer, and P. L. Else Acyl composition of muscle membranes varies with body size in birds J. Exp. Biol., November 15, 2002; 205(22): 3561 - 3569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Guderley and J. St-Pierre Going with the flow or life in the fast lane: contrasting mitochondrial responses to thermal change J. Exp. Biol., August 1, 2002; 205(15): 2237 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Boutilier and J. St-Pierre Adaptive plasticity of skeletal muscle energetics in hibernating frogs: mitochondrial proton leak during metabolic depression J. Exp. Biol., August 1, 2002; 205(15): 2287 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tadano-Aritomi, T. Hikita, A. Suzuki, H. Toyoda, T. Toida, T. Imanari, and I. Ishizuka Determination of lipid-bound sulfate by ion chromatography and its application to quantification of sulfolipids from kidneys of various mammalian species J. Lipid Res., October 1, 2001; 42(10): 1604 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shiva, P. S. Brookes, R. P. Patel, P. G. Anderson, and V. M. Darley-Usmar Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase PNAS, June 19, 2001; 98(13): 7212 - 7217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Jekabsons, F. M. Gregoire, N. A. Schonfeld-Warden, C. H. Warden, and B. A. Horwitz T3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice Am J Physiol Endocrinol Metab, August 1, 1999; 277(2): E380 - E389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Stuart, T. E. Gillis, and J. S. Ballantyne Compositional correlates of metabolic depression in the mitochondrial membranes of estivating snails Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R1977 - R1982. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
