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AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 6 1521-R1528, Copyright © 1996 by American Physiological Society
ARTICLES |
T. Woltman and R. Reidelberger
Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA.
We used the type A cholecystokinin receptor (CCK-AR) antagonist devazepide to assess the importance of CCK in mediating the anorexia produced by 2-h duodenal infusions of glucose (9.2, 11.0, and 18.3 mmol.kg-1.h-1) and the glucose dimer maltose (4.5, 6.7, and 8.5 mmol.kg-1.h-1) at the start of the dark period in nonfasted rats with free access to food. Glucose and maltose appeared to inhibit 2- to 3-h food intakes dose dependently from 19 to 91%. The highest doses of glucose and maltose administered suppressed feeding similarly by increasing first meal latency and decreasing meal frequency; lower doses produced less reliable effects on meal patterns. Devazepide appeared to completely reverse the cumulative intake responses and some of the meal pattern responses to the 9.2-mmol.kg-1.h-1 dose of glucose and to partially attenuate responses to the two higher glucose doses and to the minimal effective dose of maltose (6.7 mmol.kg-1.h-1). The magnitudes of these devazepide effects were not statistically different from those produced by devazepide when vehicle was infused duodenally. These results suggest that CCK may play a significant necessary role in mediating the satiety response to duodenal delivery of small but not large loads of glucose.
This article has been cited by other articles:
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  R. D. Reidelberger, J. Hernandez, B. Fritzsch, and M. Hulce Abdominal vagal mediation of the satiety effects of CCK in rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1005 - R1012. [Abstract] [Full Text] [PDF]
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R. D. Reidelberger, D. A. Castellanos, and M. Hulce Effects of peripheral CCK receptor blockade on food intake in rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R429 - R437. [Abstract] [Full Text] [PDF]
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R. D. Reidelberger, D. Heimann, L. Kelsey, and M. Hulce Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R389 - R398. [Abstract] [Full Text] [PDF]
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R. D. Reidelberger, L. Kelsey, D. Heimann, and M. Hulce Effects of peripheral CCK receptor blockade on gastric emptying in rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R66 - R75. [Abstract] [Full Text] [PDF]
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L. Wang, S. Cardin, V. Martinez, Y. Tache, and K. C. K. Lloyd Duodenal loading with glucose induces Fos expression in rat brain: selective blockade by devazepide Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R667 - R674. [Abstract] [Full Text] [PDF]
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T. Woltman and R. Reidelberger Role of cholecystokinin in the anorexia produced by duodenal delivery of peptone in rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1701 - R1709. [Abstract] [Full Text] [PDF]
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L. Trigazis, F. J. Vaccarino, C. E. Greenwood, and G. H. Anderson CCK-A receptor antagonists have selective effects on nutrient-induced food intake suppression in rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R323 - R330. [Abstract] [Full Text] [PDF]
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