| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 2 373-R380, Copyright © 1996 by American Physiological Society
ARTICLES |
C. J. Charles, E. A. Espiner, M. G. Nicholls, A. M. Richards, T. G. Yandle, A. Protter and T. Kosoglou
Department of Medicine, Christchurch Hospital, New Zealand.
Although many studies have examined the effects of administering natriuretic peptide receptor C (NPR-C) ligands and endopeptidase 24.11 (EP 24.11) inhibitors on clearance and bioactivity of atrial natriuretic peptide (ANP), none have systematically compared their effects on the endogenous levels of both ANP and brain natriuretic peptide (BNP) under physiological conditions. Accordingly, we examined the hemodynamic, hormonal, and renal actions of an EP 24.11 inhibitor, SCH-32615, and an NPR-C ligand, C-ANP-(4-23), both alone and in combination in eight normal conscious sheep. NPR-C blockade and EP 24.11 inhibition induce similar rises in plasma ANP, BNP, and guanosine 3',5'-cyclic monophosphate (cGMP). Synergistic increments in plasma ANP, BNP, and cGMP observed during combined administration are likely to be due to the reduced clearance of C-ANP-(4-23) in the setting of EP 24.11 inhibition, leading to increased inhibition of the receptor pathway. Combined administration was also associated with enhanced hemodynamic actions and diuretic and natriuretic effects. Our findings show that both enzymatic and receptor clearance pathways contribute equally to natriuretic peptide clearance and induce potentially important hemodynamic and renal effects in normal conscious sheep.
This article has been cited by other articles:
|
|
 |
|
  H. H. Leuchte, M. El Nounou, J. C. Tuerpe, B. Hartmann, R. A. Baumgartner, M. Vogeser, O. Muehling, and J. Behr N-terminal Pro-Brain Natriuretic Peptide and Renal Insufficiency as Predictors of Mortality in Pulmonary Hypertension Chest, February 1, 2007; 131(2): 402 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schou, M. K. Dalsgaard, O. Clemmesen, E. A. Dawson, C. C. Yoshiga, H. B. Nielsen, F. Gustafsson, P. R. Hildebrandt, and N. H. Secher Kidneys extract BNP and NT-proBNP in healthy young men J Appl Physiol, November 1, 2005; 99(5): 1676 - 1680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Chen, A. Cataliotti, J. A. Schirger, F. L. Martin, and J. C. Burnett Jr. Equimolar doses of atrial and brain natriuretic peptides and urodilatin have differential renal actions in overt experimental heart failure Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1093 - R1097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Andrew and S. Kaufman Guanylyl cyclase mediates ANP-induced vasoconstriction of murine splenic vessels Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1567 - R1571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Piquard, R. Richard, A. Charloux, S. Doutreleau, T. Hannedouche, G. Brandenberger, and B. Geny Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients J Appl Physiol, August 1, 2002; 93(2): 569 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hayashi, M. Ohtani, T. Hiraishi, and Y. Kobayashi Postoperative synthetic human atrial natriuretic peptide infusion and oral spironolactone administration for a patient with giant atria and low plasma level of atrial natriuretic peptide J. Thorac. Cardiovasc. Surg., July 1, 2002; 124(1): 206 - 209. [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Petrie, C. Hillier, F. Johnston, and J. J.V. McMurray Effect of Neutral Endopeptidase Inhibition on the Actions of Adrenomedullin and Endothelin-1 in Resistance Arteries From Patients With Chronic Heart Failure Hypertension, September 1, 2001; 38(3): 412 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Pemberton, M. L. Johnson, T. G. Yandle, and E. A. Espiner Deconvolution Analysis of Cardiac Natriuretic Peptides During Acute Volume Overload Hypertension, September 1, 2000; 36(3): 355 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Almirez and A. A. Protter Clearance of Human Brain Natriuretic Peptide in Rabbits; Effect of the Kidney, the Natriuretic Peptide Clearance Receptor, and Peptidase Activity J. Pharmacol. Exp. Ther., May 1, 1999; 289(2): 976 - 980. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. J. Pemberton, T. G. Yandle, M. T. Rademaker, C. J. Charles, G. D. Aitken, and E. A. Espiner Amino-terminal proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1200 - H1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Levin, D. G. Gardner, and W. K. Samson Natriuretic Peptides N. Engl. J. Med., July 30, 1998; 339(5): 321 - 328. [Full Text] [PDF]
|
|
|
|
|
|
M. T. Rademaker, C. J. Charles, T. Kosoglou, A. A. Protter, E. A. Espiner, M. G. Nicholls, and A. M. Richards Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2372 - H2379. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
