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Am J Physiol Regul Integr Comp Physiol 271: R25-R33, 1996;
0363-6119/96 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 271, Issue 1 25-R33, Copyright © 1996 by American Physiological Society

ARTICLES

Cortisol disposition and production rate in horses during rest and exercise

V. Lassourd, V. Gayrard, V. Laroute, M. Alvinerie, P. Benard, D. Courtot and P. L. Toutain
Ecole Nationale Veterinaire de Toulouse, Departement de Physiopathologie, France.

The influence of a 56-km endurance exercise on cortisol kinetics and production rate was evaluated in six horses administered [3H]cortisol. Exercise resulted in an immediate two- to threefold increase in plasma cortisol, with values returning very rapidly to preexercise levels. During exercise, clearance and steady-state volume of distribution of total cortisol were greatly increased (338 +/- 95 vs. 137 +/- 34 ml.kg-1.h-1 for clearance and 359 +/- 82 vs. 229 +/- 18 ml/kg for volume of distribution), whereas the terminal half-life decreased significantly (0.97 +/- 0.16 vs. 1.55 +/- 0.33 h). The estimated cortisol production rate was 4.41 +/- 1.06 micrograms.kg-1.h-1 at rest and 26.75 +/- 5.11 micrograms.kg-1.h-1 during exercise. We conclude that exercise triggers a large increase (x 6) in the adrenal secretion rate, which is not accurately reflected by the more limited increase (x 2-3) in plasma cortisol concentration, the actual measurement of plasma cortisol clearance being a prerequisite to assessment of adrenal gland function during exercise.


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A nonlabeled method to evaluate cortisol production rate by modeling plasma CBG-free cortisol disposition
Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E946 - E956.
[Abstract] [Full Text] [PDF]


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