AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 269: R245-R251, 1995;
0363-6119/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blackburn, R. E.
Right arrow Articles by Verbalis, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blackburn, R. E.
Right arrow Articles by Verbalis, J. G.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 269, Issue 2 245-R251, Copyright © 1995 by American Physiological Society

ARTICLES

Central oxytocin and ANP receptors mediate osmotic inhibition of salt appetite in rats

R. E. Blackburn, W. K. Samson, R. J. Fulton, E. M. Stricker and J. G. Verbalis
Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA.

These studies evaluated the involvement of central oxytocin (OT) and atrial natriuretic peptide (ANP) receptors in the osmotic inhibition of hypovolemia-induced salt appetite. Rats were pretreated centrally with the A chain of the cytotoxin ricin conjugated to OT (rAOT) or ANP (rAANP) to selectively inactivate cells bearing these respective receptors, or rats were pretreated with the unconjugated A chain (rA) as a control. Hypovolemia was induced with subcutaneous colloid injections, and rats then were given either 2 M mannitol, which raises plasma osmolality but lowers plasma sodium, or 1 M NaCl, which raises both. Hypertonic mannitol inhibited saline ingestion in rA-treated control rats but stimulated ingestion in rAOT- and rAANP-treated rats, whereas hypertonic NaCl blunted saline ingestion in rA- and rAOT-treated rats but stimulated ingestion in rAANP-treated rats. Angiotensin II-induced saline intake was similarly potentiated in rAOT- and rAANP-treated rats, indicating that this treatment also activates central inhibitory OT and ANP pathways. These data suggest that central ANP receptors mediate both Na(+)- and osmolality-induced inhibition of NaCl ingestion, whereas central OT receptors primarily mediate osmolality-induced inhibition of NaCl ingestion in rats.


This article has been cited by other articles:


Home page
 Exp PhysiolHome page
J. C. Geerling and A. D. Loewy
Central regulation of sodium appetite
Exp Physiol, February 1, 2008; 93(2): 177 - 209.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
A. P. de Magalhaes-Nunes, D. Badaue-Passos Jr, R. R. Ventura, D. da Silva Guedes Jr, J. P. Araujo, P. C. Granadeiro, H. K. Milanez-Barbosa, R. H. da Costa-e-Sousa, M. A. de Medeiros, J. Antunes-Rodrigues, et al.
Neuroendocrinology/Endocrinology: Sertraline, a selective serotonin reuptake inhibitor, affects thirst, salt appetite and plasma levels of oxytocin and vasopressin in rats
Exp Physiol, September 1, 2007; 92(5): 913 - 922.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
P. L. Cedraz-Mercez, A. S. Mecawi, A. Lepletier, I. G. Araujo, R. H. Costa-e-Sousa, F. F. Rocha, E. L. Olivares, M. A. Medeiros, and L. C. Reis
Neuroendocrinology/Endocrinology: Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats
Exp Physiol, September 1, 2007; 92(5): 923 - 931.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Stricker, M. A. Bushey, M. L. Hoffmann, M. McGhee, A. M. Cason, and J. C. Smith
Inhibition of NaCl appetite when DOCA-treated rats drink saline
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R652 - R662.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Stricker, J. G. Verbalis, D. A. Fitts, A. A. Ruhf, D. K. Zierath, S. N. Thornton, A. K. Johnson, and R. L. Thunhorst
Inhibition of salt appetite in rats by central oxytocin
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R487 - R488.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Krzan, M. Stenovec, M. Kreft, T. Pangrsic, S. Grilc, P. G. Haydon, and R. Zorec
Calcium-Dependent Exocytosis of Atrial Natriuretic Peptide from Astrocytes
J. Neurosci., March 1, 2003; 23(5): 1580 - 1583.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
G. Gimpl and F. Fahrenholz
The Oxytocin Receptor System: Structure, Function, and Regulation
Physiol Rev, April 1, 2001; 81(2): 629 - 683.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. S. Weisinger, J. R. Blair-West, P. Burns, D. A. Denton, and B. Purcell
Cerebral Na concentration, Na appetite and thirst of sheep: influence of somatostatin and losartan
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R686 - R694.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
W. K. Samson, Z. T. Resch, T. C. Murphy, T. T. Vargas, and D. A. Schell
Adrenomedullin: Is There Physiological Relevance in the Pathology and Pharmacology?
Physiology, December 1, 1999; 14(6): 255 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. S. Curtis, W. Huang, A. F. Sved, J. G. Verbalis, and E. M. Stricker
Impaired osmoregulatory responses in rats with area postrema lesions
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R209 - R219.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. R. Levin, D. G. Gardner, and W. K. Samson
Natriuretic Peptides
N. Engl. J. Med., July 30, 1998; 339(5): 321 - 328.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online