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Am J Physiol Regul Integr Comp Physiol 267: R612-R615, 1994;
0363-6119/94 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 2 612-R615, Copyright © 1994 by American Physiological Society

ARTICLES

L-ethionine, an amino acid analogue, stimulates eating in rats

N. E. Rawson, P. M. Ulrich and M. I. Friedman
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104.

The fructose analogue 2,5-anhydro-D-mannitol (2,5-AM) triggers feeding in rats through its actions in liver, which include a decrease in ATP due to trapping of phosphate. To determine whether decreasing liver ATP by a different means would also trigger feeding, we gave rats L-ethionine (ETH), an amino acid analogue that reduces ATP in liver by trapping adenosine as S-adenosyl-L-ethionine. ETH-treatment increased food intake from 4 to 8 h after administration, without affecting 24-h intake. Two hours after treatment, liver ATP was 25% lower in rats given ETH than in vehicle-treated controls. Circulating fuels and liver lactate and pyruvate were not affected by ETH treatment, whereas liver glycogen was 15% lower in ETH-treated rats. These results are the first to show that an amino acid analogue elicits feeding in rats fed protein-sufficient diets. Because a decrease in liver ATP is the only common effect of ETH and 2,5-AM observed thus far, a signal related to liver ATP status may be involved in the mechanism for initiation of feeding in rats.


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