AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 2 400-R407, Copyright © 1994 by American Physiological Society

ARTICLES

Coordination of the cardiac-related discharges of sympathetic nerves with different targets

G. L. Gebber, S. Zhong, S. M. Barman and H. S. Orer
Department of Pharmacology/Toxicology, Michigan State University, East Lansing 48824-11317.

Partial coherence analysis was used to remove the influences of pulse-synchronous baroreceptor nerve activity (as reflected by the arterial pulse) on the coherence of the cardiac-related discharges of sympathetic nerve pairs in unanesthetized decerebrate cats. It can be predicted that the peak at the heart rate frequency in the ordinary coherence function relating the discharges of two nerves will be eliminated by either partialization using the arterial pulse or surgical baroreceptor denervation, if the central circuits controlling the nerves share baroreceptor inputs but are not interconnected. Contrary to this prediction, in many experiments the peak was not eliminated by partialization using the arterial pulse. Moreover, partialization often nonuniformly reduced the peaks at the heart rate frequency in the coherence functions for different nerve pairs. These results are consistent with a model of multiple routes over which baroreceptor influences are distributed to the central circuits controlling different sympathetic nerves. Specifically, we propose that the direct route from the baroreceptors to each of the central circuits is complemented by cross talk among the central circuits.

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