AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 1 150-R155, Copyright © 1994 by American Physiological Society
Effect of postgastric energy loads on intake of sham meals of different palatability in rats
D. Rigaud, D. Betoulle, A. Chauvel, L. A. Alberto and M. Apfelbaum
Unite de Recherches en Nutrition Humaine, Institut National de la Sante et de la Recherche Medicale U. 286, Faculte Xavier Bichat, Paris, France.
Food intake depends on the palatability of the diet and on the energy
delivered to the body. It is not known, however, whether the palatability
of a diet is able to modulate the inhibitory effect of energy input on food
intake. To address this question, we have measured intake during sham
feeding for diets of different palatabilities in rats receiving varying
levels of duodenal energy load. Rats were offered sucrose solutions (6, 10,
or 30%) or mixed liquid diets without or with physiological duodenal energy
loads using a mixed liquid diet. Compared with that seen during real
feeding, meal size during sham feeding was increased for palatable diets
but not for less palatable diets. Intraduodenal infusion of the mixed
liquid diet inhibited the intake of all diets given by sham feeding. This
inhibition was dependent on the level of duodenal energy load and was
significantly greater for more palatable diets than for less palatable
ones. We conclude that the inhibitory effects of intestinal nutrient load
on intake are significant for all diets but have a more pronounced effect
on the intake of highly palatable diets.
