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Am J Physiol Regul Integr Comp Physiol 267: R115-R123, 1994;
0363-6119/94 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 267, Issue 1 115-R123, Copyright © 1994 by American Physiological Society

ARTICLES

beta-Adrenergic control of lipolysis in primate white fat cells: a comparative study with nonprimate mammals

A. Bousquet-Melou, J. Galitzky, C. Carpene, M. Lafontan and M. Berlan
Institut National de la Sante et de la Recherche Medicale Unite 317, Faculte de Medecine, Universite Paul Sabatier, Toulouse, France.

The beta-adrenoceptor subtypes involved in the control of lipolysis in white fat cells of rat, dog, marmoset (Callithrix jacchus), baboon (Papio papio), macaque (Macaca fascicularis), and human were compared. In all species [3H]CGP-12177 binding (up to 3 nM) indicated the existence of a homogeneous population of binding sites in fat cell membranes, and competition studies showed that beta 1- and beta 2-adrenoceptors were present. Selective beta 1 or beta 2-adrenoceptor agonists induced lipolysis. The efficiencies of isoproterenol and norepinephrine were similar. The use of selective beta 3-adrenoceptor agonists revealed that BRL-37344 and CL-316243 were full agonists, whereas CGP-12177 and SR-58611A were partial agonists in rat and dog white fat cells. beta 3-Agonists partially stimulated lipolysis in the marmoset, while CGP-12177 was weakly active in the baboon. In macaque and human fat cells, beta 3-agonists were ineffective. The lipolytic effect of norepinephrine involves beta 1-and/or beta 2-adrenoceptors in baboon, macaque, and human. The baboon and macaque constitute valuable models for studying the beta-adrenergic control of lipolysis.


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C. Sengenes, A. Zakaroff-Girard, A. Moulin, M. Berlan, A. Bouloumie, M. Lafontan, and J. Galitzky
Natriuretic peptide-dependent lipolysis in fat cells is a primate specificity
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R257 - R265.
[Abstract] [Full Text] [PDF]


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