AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 266: R1962-R1969, 1994;
0363-6119/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Convertino, V. A.
Right arrow Articles by Vernikos, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Convertino, V. A.
Right arrow Articles by Vernikos, J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 266, Issue 6 1962-R1969, Copyright © 1994 by American Physiological Society

ARTICLES

Effect of simulated microgravity on cardiopulmonary baroreflex control of forearm vascular resistance

V. A. Convertino, D. F. Doerr, D. A. Ludwig and J. Vernikos
Physiology Research Branch, Brooks Air Force Base, Texas 78235.

The stimulus-response characteristics of cardiopulmonary baroreflex control of forearm vascular resistance (FVR) were studied in 11 healthy men before and after 7 days of 6 degrees head-down bedrest to test the hypothesis that microgravity alters this reflex response. We assessed the relationship between stimulus [changes in central venous pressure (delta CVP)] and reflex response (delta FVR) during unloading of cardiopulmonary baroreceptors with lower body negative pressure (LBNP; 0 to -20 mmHg). delta CVP during bedrest and LBNP was estimated from peripheral vein pressures in the dependent right arm. Compared with prebedrest baseline, plasma volume and estimated CVP were decreased by 13 and 33%, respectively, at 7 days of bedrest. Progressive reflex forearm vasoconstriction occurred in response to graded reductions in estimated CVP during LBNP, and delta FVR per unit delta CVP was doubled after bedrest. The increase in sensitivity of the cardiopulmonary baroreflex control of FVR was related to reduced circulating blood volume, suggesting that enhanced peripheral vasoconstriction in individuals adapted to microgravity can be attributed, in part, to hypovolemia. In addition, microgravity appears to alter the stimulus for cardiopulmonary baroreceptors to a lower operational range of CVP, suggesting the possibility of chronic resetting.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
D. Fischer, P. Arbeille, J. K. Shoemaker, D. D. O'Leary, and R. L. Hughson
Altered hormonal regulation and blood flow distribution with cardiovascular deconditioning after short-duration head down bed rest
J Appl Physiol, December 1, 2007; 103(6): 2018 - 2025.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Spaak, S. Montmerle, P. Sundblad, and D. Linnarsson
Long-term bed rest-induced reductions in stroke volume during rest and exercise: cardiac dysfunction vs. volume depletion
J Appl Physiol, February 1, 2005; 98(2): 648 - 654.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. W. Waters, S. H. Platts, B. M. Mitchell, P. A. Whitson, and J. V. Meck
Plasma volume restoration with salt tablets and water after bed rest prevents orthostatic hypotension and changes in supine hemodynamic and endocrine variables
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H839 - H847.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Aljuri, R. Marini, and R. J. Cohen
Test of dynamic closed-loop baroreflex and autoregulatory control of total peripheral resistance in intact and conscious sheep
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2274 - H2286.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. H. Cooke, K. L. Ryan, and V. A. Convertino
Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans
J Appl Physiol, April 1, 2004; 96(4): 1249 - 1261.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Kamiya, D. Michikami, Q. Fu, S. Iwase, J. Hayano, T. Kawada, T. Mano, and K. Sunagawa
Pathophysiology of orthostatic hypotension after bed rest: paradoxical sympathetic withdrawal
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1158 - H1167.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. J. Mueller and E. M. Hasser
Enhanced sympathoinhibitory response to volume expansion in conscious hindlimb-unloaded rats
J Appl Physiol, May 1, 2003; 94(5): 1806 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L.-F. Zhang
Vascular adaptation to microgravity: what have we learned?
J Appl Physiol, December 1, 2001; 91(6): 2415 - 2430.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. A. Convertino, D. A. Ludwig, J. J. Elliott, and C. E. Wade
Evidence for central venous pressure resetting during initial exposure to microgravity
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R2021 - R2028.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. A. Convertino
Mechanisms of blood pressure regulation that differ in men repeatedly exposed to high-G acceleration
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R947 - R958.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Kamiya, S. Iwase, H. Kitazawa, T. Mano, O. L. Vinogradova, and I. B. Kharchenko
Baroreflex control of muscle sympathetic nerve activity after 120 days of 6{degrees} head-down bed rest
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R445 - R452.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. A. Convertino
Gender differences in autonomic functions associated with blood pressure regulation
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R1909 - R1920.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. C. Koenig, V. A. Convertino, J. W. Fanton, C. A. Reister, F. A. Gaffney, D. A. Ludwig, V. P. Krotov, E. V. Trambovetsky, and R. D. Latham
Evidence for increased cardiac compliance during exposure to simulated microgravity
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1343 - R1352.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Shoemaker, C. S. Hogeman, D. H. Silber, K. Gray, M. Herr, and L. I. Sinoway
Head-down-tilt bed rest alters forearm vasodilator and vasoconstrictor responses
J Appl Physiol, May 1, 1998; 84(5): 1756 - 1762.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Shoemaker, C. S. Hogeman, U. A. Leuenberger, M. D. Herr, K. Gray, D. H. Silber, and L. I. Sinoway
Sympathetic discharge and vascular resistance after bed rest
J Appl Physiol, February 1, 1998; 84(2): 612 - 617.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. S. Kimmerly and J. K. Shoemaker
Hypovolemia and neurovascular control during orthostatic stress
Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H645 - H655.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. H. Khan, A. R. Kunselman, U. A. Leuenberger, W. R. Davidson Jr., C. A. Ray, K. S. Gray, C. S. Hogeman, and L. I. Sinoway
Attenuated sympathetic nerve responses after 24 hours of bed rest
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2210 - H2215.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online