| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 266, Issue 5 1470-R1476, Copyright © 1994 by American Physiological Society
ARTICLES |
C. Qiu, K. Engels and C. Baylis
Department of Physiology, West Virginia University, Morgantown 26506-9229.
Nitric oxide (NO) is a tonically produced vasodilator that maintains blood pressure (BP) in the normal animal. In these studies, we produced chronic NO blockade by oral administration of the NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME), which produced sustained hypertension and increased renal vascular resistance (RVR) in conscious rats. Acute blockade of the angiotensin II type 1 (AT1) receptor with losartan had little effect on BP and RVR in either chronically NO-blocked or normal conscious rats. Acute blockade of the alpha 1-adrenoceptor with prazosin produced moderate similar falls in BP in both chronically NO-blocked and normal rats. The combination of AT1 and alpha 1-adrenoceptor blockade was profoundly antihypertensive and was particularly effective in lowering BP in chronically NO-blocked rats where the hypertension was obliterated. In contrast, the increased RVR persisted in chronically NO-blocked rats receiving combined acute AT1 and alpha 1-adrenoceptor blockade. These observations indicate that, in the sustained phase of chronic NO blockade, the hypertension is largely due to the combined activities of alpha 1-adrenoceptor and AT1 stimulation.
This article has been cited by other articles:
|
|
 |
|
  L. A. Fortepiani, M. C. O. Ruiz, F. Passardi, M. D. Bentley, J. Garcia-Estan, E. L. Ritman, and J. C. Romero Effect of losartan on renal microvasculature during chronic inhibition of nitric oxide visualized by micro-CT Am J Physiol Renal Physiol, November 1, 2003; 285(5): F852 - F860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Eshima, Y. Hirooka, H. Shigematsu, I. Matsuo, G. Koike, K. Sakai, and A. Takeshita Angiotensin in the Nucleus Tractus Solitarii Contributes to Neurogenic Hypertension Caused by Chronic Nitric Oxide Synthase Inhibition Hypertension, August 1, 2000; 36(2): 259 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Bergamaschi, R. R. Campos, and O. U. Lopes Rostral Ventrolateral Medulla : A Source of Sympathetic Activation in Rats Subjected to Long-Term Treatment With L-NAME Hypertension, October 1, 1999; 34(4): 744 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kriston, R. C. Venuto, C. Baylis, and G. Losonczy Hemodynamic and renal effects of U-46619, a TXA2/PGH2 analog, in late-pregnant rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R831 - R837. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Baylis, J. Harvey, B. R. Santmyire, and K. Engels Pressor and Renal Vasoconstrictor Responses to Acute Systemic Nitric Oxide Synthesis Inhibition Are Independent of the Sympathetic Nervous System and Angiotensin II J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 693 - 698. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. A. FORTEPIANI, E. RODRIGO, M. C. ORTÍZ, V. CACHOFEIRO, N. M. ATUCHA, L. M. RUILOPE, V. LAHERA, and J. GARCÍA-ESTAÑ Pressure Natriuresis in Nitric Oxide-Deficient Hypertensive Rats: Effect of Antihypertensive Treatments J. Am. Soc. Nephrol., January 1, 1999; 10(1): 21 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
R. Zatz and C. Baylis Chronic Nitric Oxide Inhibition Model Six Years On Hypertension, December 1, 1998; 32(6): 958 - 964. [Full Text] [PDF]
|
|
|
|
 |
|
 J.-L. Liu, H. Murakami, and I. H. Zucker Angiotensin II–Nitric Oxide Interaction on Sympathetic Outflow in Conscious Rabbits Circ. Res., March 9, 1998; 82(4): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Ortiz, L. A. Fortepiani, F. M. Ruiz-Marcos, N. M. Atucha, and J. Garcia-Estan Role of AT1 receptors in the renal papillary effects of acute and chronic nitric oxide inhibition Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R760 - R766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Kanagy Increased vascular responsiveness to alpha 2-adrenergic stimulation during NOS inhibition-induced hypertension Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2756 - H2764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Henrion, F. J. Dowell, B. I. Levy, and J.-B. Michel In Vitro Alteration of Aortic Vascular Reactivity in Hypertension Induced by Chronic NG-Nitro-L-Arginine Methyl Ester Hypertension, September 1, 1996; 28(3): 361 - 366. [Abstract] [Full Text]
|
|
|
|
|
|
S. S. Yamada, A. L. Sassaki, C. K. Fujihara, D. M. Avancini Costa Malheiros, G. De Nucci, and R. Zatz Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade Hypertension, May 1, 1996; 27(5): 1165 - 1172. [Abstract] [Full Text]
|
|
|
|
|
|
M. O. Ribeiro, E. Antunes, M. N. Muscara, G. De Nucci, and R. Zatz Nifedipine Prevents Renal Injury in Rats With Chronic Nitric Oxide Inhibition Hypertension, July 1, 1995; 26(1): 150 - 155. [Abstract] [Full Text]
|
|
|
|
|
|
C. Qiu, K. Engels, L. Samsell, and C. Baylis Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade Hypertension, January 1, 1995; 25(1): 61 - 66. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
