AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 5 1126-R1131, Copyright © 1993 by American Physiological Society

ARTICLES

Role of endothelium-derived nitric oxide in control of renal microvasculature in aging male rats

J. F. Reckelhoff and R. D. Manning Jr
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.

The objective of this study was to evaluate the role of nitric oxide (NO) in the regulation of whole kidney and glomerular hemodynamics during aging. After 2 wk of oral treatment with N-nitro-L-arginine methyl ester (L-NAME; 4.5 mg.kg body wt-1.day-1) to inhibit NO synthesis, male rats, aged 3-5, 13-15, and 21-24 mo, were studied by micropuncture. Blood pressure increased by 50% in old (21-24 mo) rats with L-NAME but only 20-30% in the two younger groups. With L-NAME, renal vascular resistance increased fivefold in old rats but only twofold in younger groups. Glomerular capillary pressure increased 20-30% in younger L-NAME rats and 60% in older rats. Afferent and efferent resistances increased dramatically, and the glomerular capillary ultrafiltration coefficient decreased in all L-NAME-treated rats but most strikingly in the 21- to 24-mo-old group. Acute infusion of L-arginine significantly attenuated the effects of NO synthase inhibition on arterial pressure and renal hemodynamics in both young and old rats. This study confirms that NO synthesis blockade has a greater effect on renal hemodynamics in aging rats and implies that NO may play a progressively more important role in controlling renal function with advancing age.

This article has been cited by other articles:

				C. Baylis Sexual Dimorphism of the Aging Kidney: Role of Nitric Oxide Deficiency Physiology, June 1, 2008; 23(3): 142 - 150. [Abstract] [Full Text] [PDF]

				J. F. Reckelhoff, L. L. Yanes, R. Iliescu, L. A. Fortepiani, and J. P. Granger Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease Am J Physiol Renal Physiol, November 1, 2005; 289(5): F941 - F948. [Abstract] [Full Text] [PDF]

				L. Yanes, D. Romero, R. Iliescu, V. E. Cucchiarelli, L. A. Fortepiani, F. Santacruz, W. Bell, H. Zhang, and J. F. Reckelhoff Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R903 - R908. [Abstract] [Full Text] [PDF]

				G. H. ALLCOCK, M. HUKKANEN, J. M. POLAK, J. S. POLLOCK, and D. M. POLLOCK Increased Nitric Oxide Synthase-3 Expression in Kidneys of Deoxycorticosterone Acetate-Salt Hypertensive Rats J. Am. Soc. Nephrol., November 1, 1999; 10(11): 2283 - 2289. [Abstract] [Full Text]

				J. F. Reckelhoff, H. Zhang, K. Srivastava, and J. P. Granger Gender Differences in Hypertension in Spontaneously Hypertensive Rats : Role of Androgens and Androgen Receptor Hypertension, October 1, 1999; 34(4): 920 - 923. [Abstract] [Full Text] [PDF]

				J. F. Reckelhoff, V. Kanji, L. C. Racusen, A. M. Schmidt, S. Du Yan, J. Morrow, L. J. Roberts II, and A. K. Salahudeen Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R767 - R774. [Abstract] [Full Text] [PDF]

				A. Zuckerman, P. N. Chander, G. A. Zeballos, and C. T. Stier Jr Regional Renal Nitric Oxide Release in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, December 1, 1997; 30(6): 1479 - 1486. [Abstract] [Full Text]

				Y. Higashi, T. Oshima, R. Ozono, H. Matsuura, and G. Kajiyama Aging and Severity of Hypertension Attenuate Endothelium-Dependent Renal Vascular Relaxation in Humans Hypertension, August 1, 1997; 30(2): 252 - 258. [Abstract] [Full Text]