AJP - Regulatory, Integrative and Comparative Physiology, Vol 265, Issue 5 1121-R1125, Copyright © 1993 by American Physiological Society
Role of prostaglandins in exercise-induced core temperature elevation in female Sprague-Dawley rats
P. J. Rowsey, K. T. Borer and M. J. Kluger
Division of Kinesiology, University of Michigan, Ann Arbor 48109.
Female Sprague-Dawley rats (12:12-h photoperiod; body temperature, BT,
measured with biotelemetry) with access to running wheels for 6 wk have an
elevated BT (compared with rats with no access to exercise wheels, i.e,
sedentary) both during the period of voluntary exercise (nighttime) (0.5
degree C, P = 0.0001) and the nonexercise period (daytime) (0.3 degree C, P
= 0.002). To determine whether prostaglandin (PG) E was responsible for any
portion of this daytime rise in BT, we injected a dose of sodium salicylate
(300 mg/kg), which was shown to produce complete antipyresis in rats
injected with lipopolysaccharide (LPS), into exercised and sedentary rats 4
h after the onset of the lights-on period. The injections of sodium
salicylate led to a fall in body temperature in both the exercised and
sedentary rats of similar amounts (-0.88 degree C vs. -0.61 degree C at 2 h
postinjection, P = 0.59). We conclude that the increase in daytime BT of
exercised female rats is not mediated by prostaglandins.
