AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 5 912-R916, Copyright © 1993 by American Physiological Society

ARTICLES

Abdominal vagotomy decreases the satiating potency of CCK-8 in sham and real feeding

K. Joyner, G. P. Smith and J. Gibbs
Department of Psychiatry, Cornell University Medical College, New York.

To compare the effect of total abdominal vagotomy on the satiating potency of cholecystokinin COOH-terminal octapeptide (CCK-8) in sham feeding and real feeding, we administered CCK-8 intraperitoneally (2, 4, and 8 micrograms/kg) 1 min before a sham feeding or real feeding intake test. CCK-8 was at least as potent for inhibiting intake during sham feeding as it was during real feeding. Total abdominal vagotomy decreased the satiating potency of all three doses of CCK-8 equally in both feeding conditions. These results are consistent with the proposal that abdominal vagal afferent fibers are as necessary for the mediation of the satiating effect of CCK-8 in sham feeding as they are in real feeding.

This article has been cited by other articles:

				H. van der Kleij, C. O'Mahony, F. Shanahan, L. O'Mahony, and J. Bienenstock Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1131 - R1137. [Abstract] [Full Text] [PDF]

				J.-E. Ghia, P. Blennerhassett, R. T. El-Sharkawy, and S. M. Collins The protective effect of the vagus nerve in a murine model of chronic relapsing colitis Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G711 - G718. [Abstract] [Full Text] [PDF]

				J.-E. Ghia, P. Blennerhassett, and S. M. Collins Vagus nerve integrity and experimental colitis Am J Physiol Gastrointest Liver Physiol, September 1, 2007; 293(3): G560 - G567. [Abstract] [Full Text] [PDF]

				S. Eisen, R. J. Phillips, N. Geary, E. A. Baronowsky, T. L. Powley, and G. P. Smith Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R456 - R462. [Abstract] [Full Text] [PDF]

				R. D. Reidelberger, J. Hernandez, B. Fritzsch, and M. Hulce Abdominal vagal mediation of the satiety effects of CCK in rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1005 - R1012. [Abstract] [Full Text] [PDF]

				T. Riediger, D. Zuend, C. Becskei, and T. A. Lutz The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R114 - R122. [Abstract] [Full Text]

				J. Glatzle, M. E. Kreis, K. Kawano, H. E. Raybould, and T. T. Zittel Postprandial neuronal activation in the nucleus of the solitary tract is partly mediated by CCK-A receptors Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R222 - R229. [Abstract] [Full Text] [PDF]

				J.-P. Gutzwiller, J. Drewe, S. Ketterer, P. Hildebrand, A. Krautheim, and C. Beglinger Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R189 - R195. [Abstract] [Full Text] [PDF]