AJP - Regulatory, Integrative and Comparative Physiology, Vol 264, Issue 3 601-R609, Copyright © 1993 by American Physiological Society

ARTICLES

Mechanisms of renal vasodilation after protein feeding: role of the renin-angiotensin system

L. L. Woods
Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland 97201-3098.

These studies were designed to determine the importance of the renin-angiotensin system (RAS) in the renal hemodynamic response to acute protein feeding. In chronically instrumented conscious dogs on a normal (80 meq/day) sodium intake, a 10 g/kg meal of raw beef caused glomerular filtration rate (GFR) to increase from 68 +/- 6 to 86 +/- 6 ml/min and effective renal plasma flow (ERPF) to increase from 211 +/- 14 to 263 +/- 15 ml/min. Plasma renin activity (PRA) was 0.44 +/- 0.14 ng ANG I.ml-1 x h-1 and did not change significantly. When the protocol was repeated during infusion of captopril, GFR increased from 67 +/- 11 to 97 +/- 10 ml/min, and ERPF rose from 264 +/- 74 to 392 +/- 82 ml/min after the meat meal. The dogs were then placed on a low-salt diet (approximately 7 meq/day) to physiologically activate the RAS. In sodium-restricted dogs, GFR increased from 71 +/- 7 to 104 +/- 10 ml/min and ERPF increased from 226 +/- 15 to 299 +/- 21 ml/min after the meat meal. PRA was 3.1 +/- 1.0 ng ANG I.ml-1 x h-1 and did not change. Thus neither blockade of the RAS with captopril nor activation of the RAS by salt restriction reduced the renal hemodynamic response to a meat meal. These data indicate that the RAS is relatively unimportant in the renal hemodynamic response to acute protein feeding.

This article has been cited by other articles:

				M. Chidambaram, J. A. Duncan, V. S. Lai, D. C. Cattran, J. S. Floras, J. W. Scholey, and J. A. Miller Variation in the Renin Angiotensin System throughout the Normal Menstrual Cycle J. Am. Soc. Nephrol., February 1, 2002; 13(2): 446 - 452. [Abstract] [Full Text] [PDF]