AJP - Regu AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 263: R1162-R1168, 1992;
0363-6119/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wastney, M. E.
Right arrow Articles by Henkin, R. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wastney, M. E.
Right arrow Articles by Henkin, R. I.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 5 1162-R1168, Copyright © 1992 by American Physiological Society

ARTICLES

Changes in regulation of human zinc metabolism with age

M. E. Wastney, S. Ahmed and R. I. Henkin
Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007.

To assess changes in zinc metabolism with age, kinetic studies were performed in healthy adults (26 men, 21 women) aged 20-84 yr after a single oral or intravenous bolus of 65Zn. Studies covered two consecutive 9-mo periods while subjects were on a basal dietary intake of approximately 10 mg Zn/day and while taking an additional 100 mg Zn/day orally. Zinc metabolism was analyzed by compartmental analysis using data from plasma, red blood cells, urine, feces, liver, thigh, and whole body [M. E. Wastney, R. L. Aamodt, W. F. Rumble, and R. I. Henkin. Am. J. Physiol. 251 (Regulatory Integrative Comp. Physiol. 20): R398-R408, 1986]. Changes in observed and model calculated values of zinc metabolism were assessed on age by regression. During basal state, zinc release from red blood cells decreased with age. During zinc loading, response (defined as change from basal state) of plasma zinc concentration, urinary zinc excretion, and liver zinc increased with age, while response of fraction of zinc taken up by red blood cells decreased with age. In men, response of amount of zinc absorbed increased with age and in women response of fraction of endogenous zinc excreted decreased with age. Four responses that changed with age (urinary excretion, red blood cell exchange, absorption, and endogenous excretion) occurred at previously defined sites of regulation of zinc metabolism. Results show that regulation of zinc metabolism changes with age.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
J. Ma and N. M. Betts
Zinc and Copper Intakes and Their Major Food Sources for Older Adults in the 1994-96 Continuing Survey of Food Intakes by Individuals (CSFII)
J. Nutr., November 1, 2000; 130(11): 2838 - 2843.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
I. J. Griffin, J. C. King, and S. A. Abrams
Body Weight-Specific Zinc Compartmental Masses in Girls Significantly Exceed Those Reported in Adults: A Stable Isotope Study Using a Kinetic Model
J. Nutr., October 1, 2000; 130(10): 2607 - 2612.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
M. E. Wastney, W. A. House, R. M. Barnes, and K. N. S. Subramanian
Kinetics of Zinc Metabolism: Variation with Diet, Genetics and Disease
J. Nutr., May 1, 2000; 130(5): 1355S - 1359.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online