AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 263: R1136-R1140, 1992;
0363-6119/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fenoy, F. J.
Right arrow Articles by Roman, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fenoy, F. J.
Right arrow Articles by Roman, R. J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 5 1136-R1140, Copyright © 1992 by American Physiological Society

ARTICLES

Effect of kinin receptor antagonists on renal hemodynamic and natriuretic responses to volume expansion

F. J. Fenoy and R. J. Roman
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.

The role of kinins in the natriuretic and papillary blood flow (PBF) responses to intravenous administration of 0.9% sodium chloride solution equal to 5% of body weight over 30 min was evaluated using a B1-kinin receptor antagonist (des-Arg9, [Leu8]bradykinin, 2.5 micrograms/min i.v.) and a B2-kinin receptor antagonist (D-Arg, [Hyp3,Thi5,8,D-Phe7]bradykinin, 2.5 micrograms/min i.v.). In control rats, PBF increased 43 +/- 5% after the volume expansion with saline. Administration of the B1-kinin receptor antagonist had no significant effect on basal PBF or the rise in PBF produced by volume expansion. In contrast, administration of the B2-kinin receptor antagonist decreased basal PBF by 18 +/- 3% and prevented the rise in PBF during volume expansion. Urine osmolality was lower in the rats treated with the B1-antagonist and higher in rats infused with the B2-kinin antagonist than in control animals after volume expansion (587 +/- 47 and 1,082 +/- 83 vs. 907 +/- 124 mosmol/kgH2O, respectively). The initial natriuretic response during the first 30 min after volume expansion was similar in rats given vehicle or the kinin antagonists. However, cumulative sodium excretion over the 2-h course of the experiment was significantly lower in the rats given the B2-receptor antagonist than in control rats (92 +/- 7 vs. 101 +/- 9% of the administered load). The B1-kinin receptor antagonist had no effect on cumulative sodium excretion; however, glomerular filtration rate was 30% lower in rats receiving the B1-antagonist than in control rats after volume expansion.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
S.-H. Sivritas, D. W. Ploth, and W. R. Fitzgibbon
Blockade of renal medullary bradykinin B2 receptors increases tubular sodium reabsorption in rats fed a normal-salt diet
Am J Physiol Renal Physiol, September 1, 2008; 295(3): F811 - F817.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
L. J. Mullins, M. A. Bailey, and J. J. Mullins
Hypertension, Kidney, and Transgenics: A Fresh Perspective
Physiol Rev, April 1, 2006; 86(2): 709 - 746.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. F. Milia, V. Gross, R. Plehm, J. A. De Silva Jr, M. Bader, and F. C. Luft
Normal Blood Pressure and Renal Function in Mice Lacking the Bradykinin B2 Receptor
Hypertension, June 1, 2001; 37(6): 1473 - 1479.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. S. A. Colombari, E. Colombari, O. U. Lopes, and S. L. Cravo
Afferent pathways in cardiovascular adjustments induced by volume expansion in anesthetized rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R884 - R890.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. B. Su, R. Houel, F. Heloire, F. Barbe, F. Beverelli, L. Sambin, A. Castaigne, A. Berdeaux, B. Crozatier, and L. Hittinger
Stimulation of Bradykinin B1 Receptors Induces Vasodilation in Conductance and Resistance Coronary Vessels in Conscious Dogs : Comparison With B2 Receptor Stimulation
Circulation, April 18, 2000; 101(15): 1848 - 1853.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Tornel, M. I. Madrid, M. Garcia-Salom, K. J. Wirth, and F. J. Fenoy
Role of Kinins in the Control of Renal Papillary Blood Flow, Pressure Natriuresis, and Arterial Pressure
Circ. Res., March 17, 2000; 86(5): 589 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
F. Marceau, J. F. Hess, and D. R. Bachvarov
The B1 Receptors for Kinins
Pharmacol. Rev., September 1, 1998; 50(3): 357 - 386.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Wang, P. Ford, C. Chao, L. Chao, and J. Chao
Effect of cyclosporin A on the expression of tissue kallikrein, kininogen, and bradykinin receptor in rat
Am J Physiol Renal Physiol, November 1, 1997; 273(5): F783 - F789.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. S. Margolius
Kallikreins and Kinins : Some Unanswered Questions About System Characteristics and Roles in Human Disease
Hypertension, August 1, 1995; 26(2): 221 - 229.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online