AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 263: R1093-R1098, 1992;
0363-6119/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Powers, S. K.
Right arrow Articles by Silverman, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Powers, S. K.
Right arrow Articles by Silverman, H.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 5 1093-R1098, Copyright © 1992 by American Physiological Society

ARTICLES

Exercise-induced cellular alterations in the diaphragm

S. K. Powers, D. Criswell, F. K. Lieu, S. Dodd and H. Silverman
Department of Exercise Science, University of Florida, Gainesville 32611.

Limited data exist concerning the effects of exercise training on cellular oxidative capacity in the diaphragm of senescent animals. In this study we examined the changes in cellular oxidative capacity, muscle cell cross-sectional area (CSA), and capillarity within the costal diaphragm of senescent animals after a 10-wk endurance-training program. Twelve 24-mo-old female Fischer 344 rats were divided into either a sedentary control group (n = 6) or exercise training group (n = 6). The trained animals exercised on a motor-driven treadmill (60 min/day, 5 days/wk) at a work rate equal to approximately 55-65% VO2max. Capillaries were identified histologically and fiber types determined using adenosinetriphosphatase (ATPase) histochemistry. Succinate dehydrogenase (SDH) activity and CSA in individual fibers were measured using a computerized image analysis system. Exercise training did not increase (P > 0.05) the capillary-to-fiber ratio for any fiber type. However, training significantly decreased CSA (P < 0.05) and increased capillary density (capillary number/CSA) (P < 0.05) in type I, type IIa, and type IIb fibers. Furthermore, exercise training resulted in small but significant increase in SDH activity (P < 0.05) in type I and IIa fibers, whereas training did not alter SDH activity (P > 0.05) in type IIb fibers. These data demonstrate that endurance training in senescent animals results in small relative improvements in both oxidative capacity and capillary density in costal diaphragmatic type I and IIa muscle fibers. The increase in both capillary density and fiber SDH activity was largely due to a reduction in fiber CSA.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
E. van Lunteren and M. Moyer
Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels
J Appl Physiol, August 1, 2003; 95(2): 602 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. L. Staib, S. J. Swoap, and S. K. Powers
Diaphragm contractile dysfunction in MyoD gene-inactivated mice
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R583 - R590.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Fournier and M. I. Lewis
Functional, cellular, and biochemical adaptations to elastase-induced emphysema in hamster medial scalene
J Appl Physiol, April 1, 2000; 88(4): 1327 - 1337.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online