AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 4 813-R819, Copyright © 1992 by American Physiological Society

ARTICLES

Dynamics of gastric emptying during and after stomach fill

J. M. Kaplan, A. C. Spector and H. J. Grill
Department of Psychology, University of Pennsylvania, Philadelphia 19104.

Gastric contents were sampled at various points during and after intragastric infusions of glucose solution (6.25, 12.5, 25%) delivered at rates typical of normal ingestion in the rat. The postinfusion results were consistent with those reported in the literature in that glucose solute emptied at a relatively stable rate over time and across stimulus concentrations. During fill (1.0 ml/min; experiment 1), by contrast, solute (caloric) emptying rate increased about threefold as stimulus concentration was raised. For each concentration, emptying rate was uniformly higher during than after fill (approximately 4 times higher at the lowest concentration). In experiment 2, gastric emptying rate during 12-min intragastric infusions of 12.5% glucose varied directly with the volumetric rate (0.5, 1.0, 2.0 ml/min) at which they were delivered. These results show that different rules govern gastric emptying during and after stomach fill. The results also suggest that a large proportion of a liquid meal may empty before feeding is terminated and that variations in the rate of ingestion could affect the gastric/postgastric distribution of ingesta and, in turn, the satiation process.

This article has been cited by other articles:

				M. A. Zafra, F. Molina, and A. Puerto Learned flavor preferences induced by intragastric administration of rewarding nutrients: role of capsaicin-sensitive vagal afferent fibers Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R635 - R641. [Abstract] [Full Text] [PDF]

				E. M. Stricker, M. A. Bushey, M. L. Hoffmann, M. McGhee, A. M. Cason, and J. C. Smith Inhibition of NaCl appetite when DOCA-treated rats drink saline Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R652 - R662. [Abstract] [Full Text] [PDF]

				B. C. De Jonghe, A. Hajnal, and M. Covasa Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G640 - G649. [Abstract] [Full Text] [PDF]

				U. Smedh and T. H. Moran The dorsal vagal complex as a site for cocaine- and amphetamine-regulated transcript peptide to suppress gastric emptying Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R124 - R130. [Abstract] [Full Text] [PDF]

				M. R. Hayes, F. M. Chory, C. A. Gallagher, and M. Covasa Serotonin type-3 receptors mediate cholecystokinin-induced satiation through gastric distension Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R115 - R123. [Abstract] [Full Text] [PDF]

				R. Chaikomin, S. Doran, K. L. Jones, C. Feinle-Bisset, D. O'Donovan, C. K. Rayner, and M. Horowitz Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects Am J Physiol Endocrinol Metab, September 1, 2005; 289(3): E504 - E507. [Abstract] [Full Text] [PDF]

				M. K. Berry, A. Russo, J. M. Wishart, A. Tonkin, M. Horowitz, and K. L. Jones Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G655 - G662. [Abstract] [Full Text] [PDF]

				J.-P. Baird, J. B. Travers, and S. P. Travers Parametric analysis of gastric distension responses in the parabrachial nucleus Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1568 - R1580. [Abstract] [Full Text] [PDF]

				S. Eisen, J. D. Davis, E. Rauhofer, and G. P. Smith Gastric negative feedback produced by volume and nutrient during a meal in rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1201 - R1214. [Abstract] [Full Text] [PDF]

				C. K. Rayner, H. S. Park, J. M. Wishart, M.-F. Kong, S. M. Doran, and M. Horowitz Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R360 - R366. [Abstract] [Full Text] [PDF]

				T. H. Moran, S. Knipp, and G. J. Schwartz Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1282 - R1290. [Abstract] [Full Text] [PDF]

				U. Smedh, J. M. Kaplan, E. Bjorkstrand, and K. Uvnas-Moberg Dual effects of somatostatin analog octreotide on gastric emptying during and after intragastric fill Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1291 - R1296. [Abstract] [Full Text] [PDF]

				T. H. Moran, J. B. Wirth, G. J. Schwartz, and P. R. McHugh Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1999; 276(4): R997 - R1002. [Abstract] [Full Text] [PDF]

				P. van der Velde, I. Koslowsky, and H. S. Koopmans Measurement of gastric emptying during and between meal intake in free-feeding Lewis rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R597 - R605. [Abstract] [Full Text] [PDF]

				J. M. Kaplan, W. H. Siemers, U. Smedh, G. J. Schwartz, and H. J. Grill Gastric branch vagotomy and gastric emptying during and after intragastric infusion of glucose Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1786 - R1792. [Abstract] [Full Text] [PDF]

				J. M. Kaplan, W. Siemers, and H. J. Grill Effect of oral versus gastric delivery on gastric emptying of corn oil emulsions Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1263 - R1270. [Abstract] [Full Text] [PDF]