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Am J Physiol Regul Integr Comp Physiol 263: R376-R381, 1992;
0363-6119/92 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 263, Issue 2 376-R381, Copyright © 1992 by American Physiological Society

ARTICLES

Vasopressin and fetal cerebrovascular regulation

J. C. Eisenach, C. Tong, D. A. Stump and S. M. Block
Department of Anesthesia, Wake Forest University Medical Center, Winston-Salem, North Carolina 27157.

Vasopressin (AVP) may increase cerebral blood flow (CBF) during hypoxemia by selective dilatation of cerebral vessels via endothelium-derived relaxing factor (EDRF) release. To test whether this action is relevant in the fetus, we produced isocapnic hypoxemia in halothane-anesthetized pregnant ewes. Fetal infusion of a V1 AVP antagonist reduced by 55% the increase in CBF during fetal hypoxemia. To test the role of this response during development, we examined the response to AVP in intact and endothelium-denuded femoral and basilar arterial rings in vitro from fetal, newborn, and adult sheep. AVP constricted femoral rings in an endothelium-independent manner, with increased potency in newborn and fetal compared with adult rings. AVP relaxed basilar rings in an endothelium-dependent manner, which was unaffected by indomethacin treatment, with increased potency in newborn and adult compared with fetal rings. We conclude that fetal cerebral vascular endothelium is functional and responsive to AVP and that circulating AVP during fetal hypoxemia contributes to increased CBF via this effect.


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Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H2072 - H2079.
[Abstract] [Full Text] [PDF]


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