AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 262: R568-R573, 1992;
0363-6119/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cui, J.
Right arrow Articles by Himms-Hagen, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cui, J.
Right arrow Articles by Himms-Hagen, J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 4 568-R573, Copyright © 1992 by American Physiological Society

ARTICLES

Long-term decrease in body fat and in brown adipose tissue in capsaicin-desensitized rats

J. Cui and J. Himms-Hagen
Department of Biochemistry, Faculty of Medicine, University of Ottawa, Ontario, Canada.

Previous studies showed that atrophy of brown adipose tissue (BAT) of capsaicin-desensitized rats occurs rapidly and persists for up to 28 days. The rats do not, however, become any more obese than control rats, despite the frequent association of atrophied BAT with obesity. The objective of the present study was to assess longer-term effects of capsaicin desensitization on BAT and on energy balance. Rats were studied at 2.5, 3.5, and 8 mo after treatment. Major effects at 8 mo, mostly seen to a lesser extent at 3.5 mo but not at 2.5 mo, were a marked reduction in body weight that was largely attributable to a reduction in body fat but also to some stunting of growth and an atrophy or lack of growth of BAT (reduced weight and content of protein, DNA, cytochrome oxidase, and uncoupling protein). Resting metabolic rates and food intake at 8 mo were reduced in proportion to the smaller body size. We suggest that the lack of trophic influence of sensory neuropeptides on BAT proposed previously may extend to other organs, including white adipose tissue, and contribute to the reduced adiposity and the smaller body size of capsaicin-desensitized rats.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Shi, C. K. Song, A. Giordano, S. Cinti, and T. J. Bartness
Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1028 - R1037.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. R. Bowers, W. T. L. Festuccia, C. K. Song, H. Shi, R. H. Migliorini, and T. J. Bartness
Sympathetic innervation of white adipose tissue and its regulation of fat cell number
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1167 - R1175.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online