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Am J Physiol Regul Integr Comp Physiol 262: R426-R431, 1992;
0363-6119/92 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 3 426-R431, Copyright © 1992 by American Physiological Society

ARTICLES

Insulin-like growth factor I preserves host lean tissue mass in cancer cachexia

E. H. Ng, C. S. Rock, D. D. Lazarus, L. Stiaino-Coico, L. L. Moldawer and S. F. Lowry
Department of Surgery, New York Hospital-Cornell Medical Center, New York 10021.

Insulin-like growth factor I (IGF-I) has been implicated in the regulation and maintenance of skeletal muscle protein balance and thus may be of potential benefit in attenuating the cancer-cachectic process. To examine this hypothesis, 47 sham or tumor-implanted Fischer 344 rats were randomized to receive either continuous subcutaneous IGF-I (220 or 400 micrograms/day) or saline as control. In the tumor-bearing (TB) population, IGF-I-treated groups showed a dose-dependent increase in host weight gain (P less than 0.05), final carcass weight (P less than 0.05), and gastrocnemius muscle weights (P less than 0.05) and protein contents (0.50 +/- 0.02, 0.40 +/- 0.01, and 0.52 +/- 0.03 g/100 g host wt, for non-TB saline, TB saline, and TB 400 mg IGF-I groups, respectively; P less than 0.01, IGF-I vs. saline). Similar increases in muscle RNA and DNA contents (P less than 0.01) were induced by IGF-I treatment (P less than 0.05). IGF-I treatment in this rat sarcoma model significantly reduced the proportion of aneuploid cells in the tumor (aneuploid-to-diploid ratio: TB saline 1.1 +/- 0.2 vs. TB IGF-I 0.5 +/- 0.1; P less than 0.05). IGF-I treatment attenuated host muscle protein and lean tissue depletion without stimulation of tumor growth. The tumor aneuploid population was reduced in response to IGF-I treatment. Thus IGF-I may be a potential therapeutic agent in cancer-induced cachexia.


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C.-H. Fang, B.-G. Li, J. J. Wang, J. E. Fischer, and P.-O. Hasselgren
Treatment of burned rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1091 - R1098.
[Abstract] [Full Text] [PDF]


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