| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 262, Issue 3 356-R363, Copyright © 1992 by American Physiological Society
ARTICLES |
G. Goldspink, A. Scutt, P. T. Loughna, D. J. Wells, T. Jaenicke and G. F. Gerlach
Unit of Veterinary Molecular and Cellular Biology, Royal Veterinary College, London University, United Kingdom.
Striated muscle is a tissue in which gene expression is influenced to a large extent by mechanical signals. This includes the regulation of gene expression-associated muscle fiber phenotype determination, which depends on which protein isoform genes are transcribed, as well as muscle fiber mass accretion, which appears to involve some translational regulation. Although muscle synthesizes a set of highly specialized proteins it has a remarkable ability to adapt by expressing different isoforms of the same protein so that it acquires the appropriate contractile characteristics. Our work has focused on the myosin heavy chain (HC) genes as these encode the myosin cross bridge, which is responsible for muscle intrinsic velocity of contraction and economy of force development. RNA analyses after cast immobilization of the limb with the muscle in the lengthened or shortened position and/or with electrical stimulation were used to determine the effects of altered mechanical signals on gene transcription. When the soleus muscle was immobilized in the shortened position in the young animal it did not fully differentiate into a slow postural-type muscle. Even in the adult, the soleus muscle if deprived of stretch and contractile activity switches back to transcribing the fast myosin HC gene. The converse was true when the fast rabbit tibialis anterior was subjected to immobilization in the lengthened position and/or electrical stimulation. Both stretch alone and stimulation alone caused repression of the fast type and activation of the slow myosin genes. The reprogramming of the fast muscle was more complete when the stretch was combined with stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  R. Chandran, T. J. Knobloch, M. Anghelina, and S. Agarwal Biomechanical signals upregulate myogenic gene induction in the presence or absence of inflammation Am J Physiol Cell Physiol, July 1, 2007; 293(1): C267 - C276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Geiger, J. P. Bailey, C. B. Mantilla, W.-Z. Zhan, and G. C. Sieck Mechanisms underlying myosin heavy chain expression during development of the rat diaphragm muscle J Appl Physiol, December 1, 2006; 101(6): 1546 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Izquierdo, J. Ibanez, J. J. Gonzalez-Badillo, K. Hakkinen, N. A. Ratamess, W. J. Kraemer, D. N. French, J. Eslava, A. Altadill, X. Asiain, et al. Differential effects of strength training leading to failure versus not to failure on hormonal responses, strength, and muscle power gains J Appl Physiol, May 1, 2006; 100(5): 1647 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mckoy, Y. Hou, S. Y. Yang, D. Vega Avelaira, H. Degens, G. Goldspink, and G. R. Coulton Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function J Appl Physiol, June 1, 2005; 98(6): 2337 - 2343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Hornberger, D. D. Armstrong, T. J. Koh, T. J. Burkholder, and K. A. Esser Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction Am J Physiol Cell Physiol, January 1, 2005; 288(1): C185 - C194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Radzyukevich and J. A. Heiny Regulation of dihydropyridine receptor gene expression in mouse skeletal muscles by stretch and disuse Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1445 - C1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Martineau and P. F. Gardiner Insight into skeletal muscle mechanotransduction: MAPK activation is quantitatively related to tension J Appl Physiol, August 1, 2001; 91(2): 693 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Berrios, M. A. Schroeder, and R. D. Hubmayr Mechanical properties of alveolar epithelial cells in culture J Appl Physiol, July 1, 2001; 91(1): 65 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. El Oakley, O. C. Ooi, A. Bongso, and M. H. Yacoub Myocyte transplantation for myocardial repair: a few good cells can mend a broken heart Ann. Thorac. Surg., May 1, 2001; 71(5): 1724 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pette Plasticity in Skeletal, Cardiac, and Smooth Muscle: Historical Perspectives: Plasticity of mammalian skeletal muscle J Appl Physiol, March 1, 2001; 90(3): 1119 - 1124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Baldwin and F. Haddad Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle J Appl Physiol, January 1, 2001; 90(1): 345 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. GEA, Q. HAMID, G. CZAIKA, E. ZHU, V. MOHAN-RAM, G. GOLDSPINK, and A. GRASSINO Expression of Myosin Heavy-Chain Isoforms in the Respiratory Muscles Following Inspiratory Resistive Breathing Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1274 - 1278. [Abstract] [Full Text]
|
|
|
|
|
|
T. A. McBride, B. W. Stockert, F. A. Gorin, and R. C. Carlsen Stretch-activated ion channels contribute to membrane depolarization after eccentric contractions J Appl Physiol, January 1, 2000; 88(1): 91 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Y. Han, W. Wang, R. Myllyla, P. Virtanen, J. Karpakka, and T. E. S. Takala mRNA levels for alpha -subunit of prolyl 4-hydroxylase and fibrillar collagens in immobilized rat skeletal muscle J Appl Physiol, July 1, 1999; 87(1): 90 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Egginton, O. Hudlicka, M. D. Brown, H. Walter, J. B. Weiss, and A. Bate Capillary growth in relation to blood flow and performance in overloaded rat skeletal muscle J Appl Physiol, December 1, 1998; 85(6): 2025 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yang, J. Bourdon, S. B. Gottfried, W. A. Zin, and B. J. Petrof Regulation of myosin heavy chain gene expression after short-term diaphragm inactivation Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L980 - L989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gutierrez, R. F. Gonzalez, and L. G. Dobbs Mechanical distension modulates pulmonary alveolar epithelial phenotypic expression in vitro Am J Physiol Lung Cell Mol Physiol, February 1, 1998; 274(2): L196 - L202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.D. Sterne, G.R. Coulton, R.A. Brown, C.J. Green, and G. Terenghi Neurotrophin-3-enhanced Nerve Regeneration Selectively Improves Recovery of Muscle Fibers Expressing Myosin Heavy Chains 2b J. Cell Biol., November 3, 1997; 139(3): 709 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Clements, A. J. Banes, and J. E. Faber Effect of Mechanical Loading on Vascular {alpha}1D- and {alpha}1B-Adrenergic Receptor Expression Hypertension, May 1, 1997; 29(5): 1156 - 1164. [Abstract] [Full Text]
|
|
|
|
|
|
H. Jankala, V.-P. Harjola, N. E. Petersen, and M. Harkonen Myosin heavy chain mRNA transform to faster isoforms in immobilized skeletal muscle: a quantitative PCR study J Appl Physiol, March 1, 1997; 82(3): 977 - 982. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
