AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 259: R1148-R1155, 1990;
0363-6119/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilson, B. E.
Right arrow Articles by Weigle, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilson, B. E.
Right arrow Articles by Weigle, D. S.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 259, Issue 6 1148-R1155, Copyright © 1990 by American Physiological Society

ARTICLES

Identification of candidate genes for a factor regulating body weight in primates

B. E. Wilson, G. E. Meyer, J. C. Cleveland Jr and D. S. Weigle
Department of Medicine, University of Washington School of Medicine, Seattle 98195.

A weight gain of 20-30% above baseline, induced by gastrostomy overfeeding of subhuman primates or gavage overfeeding of rats, was found to completely suppress voluntary food consumption. When overfeeding was discontinued, body weight and oral intake returned in a coordinated fashion to baseline or "set point" values. This regulatory response could have been due to a circulating peptide that was secreted by adipocytes in proportion to the total body energy store and that mediated satiety at the level of the central nervous system. To search for this factor, a subtractive cDNA cloning strategy was developed, permitting the isolation of primate adipocyte genes with augmented expression in the overfed state. A 1.8-kb cDNA clone prepared by subtraction was found to hybridize to a 5-kb message expressed preferentially in the adipose tissue of overfed macaques and rats. This message, which was restricted in distribution among nonadipose tissues, was also detected in human subcutaneous fat. Candidate genes for satiety factors identified by this approach could be used in further studies of body weight regulation and obesity.


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
P. J. Havel
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Experimental Biology and Medicine, December 1, 2001; 226(11): 963 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. S. Weigle, A. M. Hutson, J. M. Kramer, M. G. M. Fallon, J. M. Lehner, S. Lok, and J. L. Kuijper
Leptin does not fully account for the satiety activity of adipose tissue-conditioned medium
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R976 - R985.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online