AJP - Regulatory, Integrative and Comparative Physiology, Vol 259, Issue 4 724-R728, Copyright © 1990 by American Physiological Society

ARTICLES

Roles of interleukin 1 beta and tumor necrosis factor in lipopolysaccharide fever in rats

N. C. Long, I. Otterness, S. L. Kunkel, A. J. Vander and M. J. Kluger
Department of Physiology, University of Michigan Medical School, Ann Arbor 48109.

The roles of interleukin 1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF) in lipopolysaccharide (LPS)-induced fever were investigated in the rat. We used antisera against IL-1 beta and TNF to determine whether we could alter the fever by blocking the action of these cytokines. The intravenous injection of antiserum IL-1 beta 3.5 days before the intraperitoneal injection of LPS resulted in a mean fever that was significantly lower than that seen in rats that had been injected with control serum (0.36 +/- 0.11 vs. 0.82 +/- 0.16 degrees C, P = 0.016). The intravenous injection of antiserum against TNF 3.5 days before the intraperitoneal injection of LPS did not block the fever but significantly enhanced it (1.31 +/- 0.16 vs. 0.82 +/- 0.16 degrees C, P = 0.027). These data support the hypotheses that IL-1 beta is responsible for a significant part of LPS fever and that TNF acts as an endogenous antipyretic to limit the magnitude of LPS fever in the rat.

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