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Am J Physiol Regul Integr Comp Physiol 259: R313-R316, 1990;
0363-6119/90 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 259, Issue 2 313-R316, Copyright © 1990 by American Physiological Society

ARTICLES

Continuous servo-controlled replacement of urinary sodium loss in conscious dogs

S. E. Andersen and P. Bie
Department of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark.

A method for continuous servo-controlled infusion of sodium chloride to dogs is reported. The servo system consists of a sodium-sensitive electrode, a modified commercial flowmeter, a thermistor, a control unit, and a pump. Based on analog inputs from electrode, flowmeter, and thermistor, the control unit generates appropriate numbers of voltage steps, which drive the pump infusing a concentrated solution of sodium chloride. Inputs from the thermistor are necessary to correct for the influence of fluctuations in urine temperature. The sodium servo system has been tested together with a weight servo mechanism in conscious water-diuretic dogs. Furosemide (1 microgram.kg-1.min-1) was infused to change the rate of sodium excretion by a factor of 17 from 3 +/- 1 to 50 +/- 15 mumols/min. Within this range, the apparatus replaced the sodium losses with great accuracy. From seven experiments the average system response in micromoles per minute (NaIn) measured in 10-min periods against mean renal excretion of sodium (NaEx) was NaIn = 0.98.NaEx - 1.37. The servo system provides a tool for accurate maintenance of body sodium irrespective of large changes in the rate of sodium excretion.


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