AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 258: R1224-R1229, 1990;
0363-6119/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sarelius, I. H.
Right arrow Articles by Huxley, V. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sarelius, I. H.
Right arrow Articles by Huxley, V. H.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 5 1224-R1229, Copyright © 1990 by American Physiological Society

ARTICLES

A direct effect of atrial peptide on arterioles of the terminal microvasculature

I. H. Sarelius and V. H. Huxley
Department of Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642.

Responses to atrial peptide (AP) were observed in cheek pouch arterioles of anesthetized golden hamsters (pentobarbital sodium, 70 mg/kg ip). Vessels for observation were selected on the basis of their functional status in relation to controlling the perfused capillary surface area. Local application of AP onto microvessels at a final concentration of from 7 X 10(-9) to 3 X 10(-8) M was achieved via micropipettes; responses were compared with those produced by application of vehicle only. Individual vessels were observed during control conditions and during vasoconstriction of the microvascular bed induced via either equilibration of the superfusate with 10% oxygen or addition to the superfusate of 5 X 10(-7) M norepinephrine (NE). Compared with responses induced by the vehicle in each condition, AP produced a statistically significant dilation during control conditions, and during raised PO2, but no statistically significant effect during NE exposure. Mean diameter changes were from a base line of 27.8 +/- 4.7 to 29.7 +/- 4.5 microns with vehicle and 33.2 +/- 4.4 microns with AP in controls; from 22.7 +/- 4.6 to 25.8 +/- 4.5 microns with vehicle and 30.1 +/- 4.7 microns with AP during raised PO2; and from 25.2 +/- 4.7 to 29.8 +/- 5.4 microns with vehicle and 33.5 +/- 4.9 microns with AP during NE exposure. The data show that arterioles of the terminal microvasculature can respond selectively to AP.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Duza and I. H. Sarelius
Conducted dilations initiated by purines in arterioles are endothelium dependent and require endothelial Ca2+
Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H26 - H37.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. L. Murrant and I. H. Sarelius
Multiple dilator pathways in skeletal muscle contraction-induced arteriolar dilations
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R969 - R978.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. L. Murrant and I. H. Sarelius
Local and remote arteriolar dilations initiated by skeletal muscle contraction
Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2285 - H2294.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. D. Cohen, B. R. Berg, and I. H. Sarelius
Remote arteriolar dilations in response to muscle contraction under capillaries
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1916 - H1923.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online