AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 258: R436-R442, 1990;
0363-6119/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kraly, F. S.
Right arrow Articles by Corneilson, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kraly, F. S.
Right arrow Articles by Corneilson, R.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 2 436-R442, Copyright © 1990 by American Physiological Society

ARTICLES

Angiotensin II mediates drinking elicited by eating in the rat

F. S. Kraly and R. Corneilson
Department of Psychology, Colgate University, Hamilton, New York 13346.

Captopril (CA) was used to block synthesis of endogenous angiotensin II (ANG II) in periphery and/or brain of adult male Sprague-Dawley rats in tests for drinking elicited by eating pelleted chow. Blockade of ANG II-converting enzyme (ACE) in periphery alone (using 0.5 mg/kg CA) increased drinking elicited by eating, whereas simultaneous blockade of ACE in periphery and brain (using subcutaneous 100 mg/kg CA or subcutaneous 0.5 mg/kg plus third ventricular 25 micrograms CA) decreased such drinking. The inhibitory effect of 100 mg/kg CA on water-to-food ratio was prevented by a dipsogenically subthreshold subcutaneous dose (5 micrograms/kg) of ANG II. Blockade of ACE in brain alone (third ventricular 25 micrograms CA) had no effect on food-related drinking. Pharmacological antagonism of ANG II (100 mg/kg CA) together with antagonism of histamine H1 and H2 receptors (using intraperitoneal dexbrompheniramine and cimetidine) were not additive in their inhibitory effects on drinking elicited by eating. Blockade of ACE (100 mg/kg CA) inhibited drinking elicited by subcutaneous histamine, but blockade of histamine receptors failed to inhibit drinking elicited by subcutaneous ANG II. These results support a role for endogenous ANG II under what appear to be physiological conditions for drinking behavior, i.e., when drinking is elicited by eating, and they suggest the working hypothesis of ANG II mediation of a histaminergic mechanism for food-related drinking in the rat.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. P. Zorrilla, K. Inoue, E. M. Fekete, A. Tabarin, G. R. Valdez, and G. F. Koob
Measuring meals: structure of prandial food and water intake of rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1450 - R1467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Starbuck and D. A. Fitts
Influence of the subfornical organ on meal-associated drinking in rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R669 - R677.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. M. Thai, H. T. Van, M. A. Gaballa, S. Goldman, and T. E. Raya
Effects of AT1 receptor blockade after myocardial infarct on myocardial fibrosis, stiffness, and contractility
Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H873 - H880.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. T. FITZSIMONS
Angiotensin, Thirst, and Sodium Appetite
Physiol Rev, July 1, 1998; 78(3): 583 - 686.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online