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Am J Physiol Regul Integr Comp Physiol 258: R291-R297, 1990;
0363-6119/90 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 2 291-R297, Copyright © 1990 by American Physiological Society

ARTICLES

Missing data in two-way analysis of variance

B. K. Slinker and S. A. Glantz
Department of Medicine, University of Vermont, Burlington 05405.

We previously described a regression approach to analysis of variance computations that permitted analysis of unbalanced designs and experiments with missing data in two-way (or higher) analyses of variance Am. J. Physiol. 255 (Regulatory Integrative Comp. Physiol. 24): R353-R367, 1988. That approach can only be used correctly under a set of narrow, and relatively uninteresting, circumstances. In fact, in the example we worked, we extended that approach beyond its intended scope and incorrectly computed F statistics for testing hypotheses about the main effects of strain of rat and nephron site in a study of renal Na(+)-K(+)-adenosinetriphosphatase. This paper presents the correct approach, which can be generalized to most situations likely to be encountered when two-way, or higher, analyses of variance are used.


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