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Am J Physiol Regul Integr Comp Physiol 258: R149-R154, 1990;
0363-6119/90 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 258, Issue 1 149-R154, Copyright © 1990 by American Physiological Society

ARTICLES

Hypertonic and hypovolemic stimulation of thirst in pigs

C. R. Anderson and T. R. Houpt
Department of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.

Young female pigs weighing from 15 to 45 kg were used. Plasma osmolality was slowly raised by an intravenous infusion of 15% NaCl. The behavioral threshold was when the pigs began to drink water, and the rise of osmolality was the stimulus. In 23 measurements on 8 pigs the rise of osmolality to initiate drinking was 10.4 +/- 1.4 mosmol/kg (mean +/- SE). There was also an estimated 3.8 +/- 1.4% rise of blood volume. Control infusions of 0.9% NaCl for 1 h usually resulted in no drinking, and plasma osmolality fell by 6.7 +/- 2.1 mosmol/kg, while blood volume did not change. Hypovolemia was effected using furosemide (1 mg/kg body wt) to cause excretion of nearly isotonic urine. Blood volume changes were estimated from plasma protein and packed cell volume data. In 28 measurements on 6 pigs, drinking occurred when blood volume had decreased by 6.7 +/- 1.8%. During 2-h control periods, blood volume did not change appreciably. Plasma osmolality decreased during both the furosemide treatment (by 3.5 +/- 0.7 mosmol/kg) and the controls (by 4.1 +/- 0.8 mosmol/kg).


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Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1999; 276(4): R1156 - R1163.
[Abstract] [Full Text] [PDF]


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