AJP - Regulatory, Integrative and Comparative Physiology, Vol 257, Issue 3 588-R594, Copyright © 1989 by American Physiological Society

ARTICLES

Central effects of somatostatin: pressor response, AVP release, and sympathoinhibition

R. Rettig, R. Geist, U. Sauer, P. Rohmeiss and T. Unger
Department of Pharmacology, University of Heidelberg, Federal Republic of Germany.

The effects of intracerebroventricular (icv) administration of somatostatin(1-14) (SS1-14) on mean arterial blood pressure (MAP), heart rate (HR), plasma arginine vasopressin (AVP) concentration, and splanchnic nerve activity (SpNA) were studied in conscious rats. In addition, the effects of peripheral alpha-adrenergic receptor blockade with prazosin, vasopressinergic V1-receptor blockade with [d(CH2)5Tyr(Me)]AVP, and chronic bilateral sinoaortic denervation (SAD) on central SS1-14-induced MAP, HR, and SpNA responses were investigated. SS1-14 icv elicited dose-dependent increases in MAP and plasma AVP concentration as well as decreases in HR and SpNA. Prazosin iv did not significantly affect SS1-14-induced pressor and bradycardic responses but augmented the decrease in SpNA. The V1-AVP receptor antagonist iv significantly attenuated the effects of SS1-14 icv on MAP, HR, and SpNA. Following SAD the pressor responses to SS1-14 icv were significantly enhanced and were associated with significantly smaller decreases in HR and SpNA. We conclude that central administration of SS1-14 causes a pressor response via release of AVP while at the same time inhibiting peripheral sympathetic outflow. Our results support the hypothesis that SS1-14 in the brain by its effects on AVP release and sympathetic outflow may participate in central cardiovascular regulation.

This article has been cited by other articles:

				Z. Liao, Z.-S. Li, Y. Lu, and W.-Z. Wang Microinjection of exogenous somatostatin in the dorsal vagal complex inhibits pancreatic secretion via somatostatin receptor-2 in rats Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G746 - G752. [Abstract] [Full Text] [PDF]

				I. Hajdu, F. Obal Jr., J. Gardi, F. Laczi, and J. M. Krueger Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R271 - R277. [Abstract] [Full Text] [PDF]