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Am J Physiol Regul Integr Comp Physiol 257: R132-R135, 1989;
0363-6119/89 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 257, Issue 1 132-R135, Copyright © 1989 by American Physiological Society

ARTICLES

Effects of hypoxia and hypocapnia on brain redox balance in ducks

P. E. Bickler, S. O. Koh and J. W. Severinghaus
Anesthesia Department, University of California, San Francisco 94143-0542.

Low arterial CO2 tension (PaCO2) experienced by birds during high-altitude flight may result in cerebral vasoconstriction with reduced cerebral O2 delivery. To test this, brain redox balance and blood volume were studied during severe hypocapnia (PaCO2 11-20 mmHg) in ducks. Cerebrocortical redox balance, measured as relative [NADH], and blood volume were measured simultaneously with a fiber-optic fluorometer-reflectometer. Cerebrocortical blood volume (an index of blood flow) fell nearly linearly with PaCO2 during severe hypocapnia, even during severe hypoxemia. Cerebrocortical redox balance was shifted toward reduction of NADH ([NADH] increased) by both hypoxemia and hypocapnia. If hypocapnia causes similar changes in brain blood flow during high-altitude flight, tissue hypoxia will be exacerbated. Tolerance of brain tissue hypoxia during flight may be an important adaptation in high-flying birds.


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