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Am J Physiol Regul Integr Comp Physiol 256: R922-R929, 1989;
0363-6119/89 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 4 922-R929, Copyright © 1989 by American Physiological Society

ARTICLES

Fish muscle energy metabolism measured by in vivo 31P-NMR during anoxia and recovery

G. van den Thillart, A. van Waarde, H. J. Muller, C. Erkelens, A. Addink and J. Lugtenburg
Department of Biology (Animal Physiology), Gorlaeus Laboratories, University of Leiden, The Netherlands.

By means of in vivo 31P nuclear magnetic resonance (NMR) we measured energy stores and intracellular pH at 10-min intervals in the myotome of unanesthetized carp and goldfish before, during, and after a period of anoxia (1 h for carp and 4 h for goldfish). The fish were mounted in a modified bioprobe, and their gills were irrigated with a constant flow of aerated or anoxic water. Anoxia caused a steep decline of phosphocreatine and intracellular pH in carp muscle. After the phosphocreatine stores had been exhausted by greater than 85%, [ATP] fell, whereas IMP and phosphodiesters accumulated. In goldfish muscle, initial changes followed the same pattern, but after 20 min a steady state of high-energy phosphates was reached and the development of acidosis was dampened. The resistance of goldfish to anoxia is due to metabolic suppression and a switch from lactate to ethanol and CO2 as the anaerobic end products. In both species, recovery was complete within 3 h. The fast pH recovery seems to be mainly caused by H+ and lactic acid efflux.


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