| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 3 659-R665, Copyright © 1989 by American Physiological Society
ARTICLES |
Y. Fong, L. L. Moldawer, M. Marano, H. Wei, A. Barber, K. Manogue, K. J. Tracey, G. Kuo, D. A. Fischman, A. Cerami and al. et
Laboratory of Surgical Metabolism, New York Hospital-Cornell Medical Center, New York 10021.
Macrophage secretory products are suspected to participate in the severe lean tissue wasting related to chronic illness. The protein metabolic effects of chronic, 7-day cachectin/tumor necrosis factor (cachectin) or interleukin 1 alpha (IL-1 alpha) administration in vivo were studied in male Wistar rats that were 1) freely fed, 2) pair fed, 3) total protein and calorie starved, 4) twice daily lipopolysaccharide (LPS) administered, 5) twice daily cachectin administered, and 6) twice daily IL-1 alpha administered. LPS, cachectin, or IL-1 alpha administration produced anorexia; weight loss in these groups was comparable to respective pair-fed animals. However, LPS, cachectin, or IL-1 alpha accelerated peripheral protein wasting while preserving liver protein content, unlike the pattern in the pair-fed or starved animals in which loss of liver proteins and relative preservation of skeletal muscle protein were observed. The decrease in skeletal muscle protein content in LPS- or cytokine-treated animals was associated with coordinate decreases in muscle mRNA levels for the myofibrillar proteins myosin heavy chain, myosin light chain, actin, and in the 18S and 28S subunits of ribosomal RNA. We conclude that chronic exposure to the cytokines, IL-1 alpha or cachectin, can simulate those body and muscle protein changes seen in experimental LPS administration or chronic disease and markedly differ from the pattern of protein redistribution due to caloric restriction.
This article has been cited by other articles:
|
|
 |
|
  J. M. Peterson, K. D. Feeback, J. H. Baas, and F. X. Pizza Tumor necrosis factor-{alpha} promotes the accumulation of neutrophils and macrophages in skeletal muscle J Appl Physiol, November 1, 2006; 101(5): 1394 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-P. Li TNF-{alpha} is a mitogen in skeletal muscle Am J Physiol Cell Physiol, August 1, 2003; 285(2): C370 - C376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. J. Langen, A. M. W. J. Schols, M. C. J. M. Kelders, J. L. J. van der Velden, E. F. M. Wouters, and Y. M. W. Janssen-Heininger Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways Am J Physiol Cell Physiol, September 1, 2002; 283(3): C714 - C721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Frost, G. J. Nystrom, and C. H. Lang Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R698 - R709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. J. LANGEN, A. M. W. J. SCHOLS, M. C. J. M. KELDERS, E. F. M. WOUTERS, and Y. M. W. JANSSEN-HEININGER Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-{kappa}B FASEB J, May 1, 2001; 15(7): 1169 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Marks, N. Ling, and R. D. Cone Role of the Central Melanocortin System in Cachexia Cancer Res., February 1, 2001; 61(4): 1432 - 1438. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. C. CREUTZBERG, E. F. M. WOUTERS, I. M. L. VANDERHOVEN-AUGUSTIN, M. A. DENTENER, and A. M. W. J. SCHOLS Disturbances in Leptin Metabolism Are Related to Energy Imbalance during Acute Exacerbations of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1239 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. IONESCU, L. S. NIXON, W. D. EVANS, M. D. STONE, V. LEWIS-JENKINS, K. CHATHAM, and D. J. SHALE Bone Density, Body Composition, and Inflammatory Status in Cystic Fibrosis Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 789 - 794. [Abstract] [Full Text]
|
|
|
|
|
|
E. C. CREUTZBERG, A. M. W. J. SCHOLS, C. A. P. M. WELING-SCHEEPERS, W. A. BUURMAN, and E. F. M. WOUTERS Characterization of Nonresponse to High Caloric Oral Nutritional Therapy in Depleted Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 745 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. van HEECKEREN, J. TSCHEIKUNA, R. W. WALENGA, M. W. KONSTAN, P. B. DAVIS, B. EROKWU, M. A. HAXHIU, and T. W. FERKOL Effect of Pseudomonas Infection on Weight Loss, Lung Mechanics, and Cytokines in Mice Am. J. Respir. Crit. Care Med., January 1, 2000; 161(1): 271 - 279. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Cooney, S. R. Kimball, R. Eckman, G. Maish III, M. Shumate, and T. C. Vary TNF-binding protein ameliorates inhibition of skeletal muscle protein synthesis during sepsis Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E611 - E619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Webel, R. W. Johnson, and D. H. Baker Lipopolysaccharide-Induced Reductions in Food Intake Do Not Decrease the Efficiency of Lysine and Threonine Utilization for Protein Accretion in Chickens J. Nutr., October 1, 1998; 128(10): 1760 - 1766. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kaibara, A. Moshyedi, T. Auffenberg, A. Abouhamze, E. M. Copeland III, S. Kalra, and L. L. Moldawer Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1518 - R1525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Moshyedi, M. D. Josephs, E. K. Abdalla, S. L. D. MacKay, C. K. Edwards III, E. M. Copeland III, and L. L. Moldawer Increased Leptin Expression in Mice with Bacterial Peritonitis is Partially Regulated by Tumor Necrosis Factor Alpha Infect. Immun., April 1, 1998; 66(4): 1800 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Lang, R. A. Frost, A. C. Nairn, D. A. MacLean, and T. C. Vary TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E336 - E347. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
