| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 2 448-R462, Copyright © 1989 by American Physiological Society
ARTICLES |
R. L. Stornetta, S. F. Morrison, D. A. Ruggiero and D. J. Reis
Department of Neurology, Cornell University Medical College, New York, New York 10021.
The somatic pressor reflex (SPR) elicited in anesthetized paralyzed rats by electrical stimulation of the sciatic or sural cutaneous afferent nerves produced an increase in arterial pressure ranging from 5 to 40 mmHg. Stimulation of femoral or tibial afferent nerves from muscle produced a depressor response. The SPR was not affected by midpontine transection but was eliminated either by hemisection of the lumbar spinal cord contralateral, but not ipsilateral, to the stimulated nerve or by electrolytic or kainic acid lesion of the contralateral, but not ipsilateral, rostral ventrolateral medulla (RVL). Stimulation of the brachial plexus elicited an SPR that was not eliminated by contralateral lumbar hemisection but was abolished by RVL lesion. RVL lesions consistently overlapped areas containing phenylethanolamine N-methyltransferase-labeled C1 adrenergic neurons. Kainic acid injections into the lateral reticular nucleus (LRN) did not affect the SPR. Neither contralateral nor ipsilateral electrolytic lesions of other autonomic areas including parabrachial nucleus, the nucleus tractus solitarii, the A5 region, or the inferior cerebellar peduncle (output pathway of the LRN) affected the reflex. In axonal transport studies using horseradish peroxidase, afferent terminals of the sciatic nerve were shown to overlap spinoreticular neurons in the dorsal horn retrogradely labeled from tracer injections in the RVL. We conclude that the SPR can be elicited in rats, that it is mediated by spinoreticular afferents traveling in the contralateral spinal cord, and that the C1 adrenergic area of the RVL is a critical region for the integration of the somatic pressor reflex.
This article has been cited by other articles:
|
|
 |
|
  C. J. Madden, S. D. Stocker, and A. F. Sved Attenuation of homeostatic responses to hypotension and glucoprivation after destruction of catecholaminergic rostral ventrolateral medulla neurons Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R751 - R759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhou, L.-W. Fu, S. C. Tjen-A-Looi, Z.-l. Guo, and J. C. Longhurst Role of glutamate in a visceral sympathoexcitatory reflex in rostral ventrolateral medulla of cats Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1309 - H1318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Nelson, J. M. Juraska, T. I. Musch, and G. A. Iwamoto Neuroplastic adaptations to exercise: neuronal remodeling in cardiorespiratory and locomotor areas J Appl Physiol, December 1, 2005; 99(6): 2312 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Crisostomo, P. Li, S. C. Tjen-A-Looi, and J. C. Longhurst Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats J Appl Physiol, June 1, 2005; 98(6): 2056 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Orer, G. L. Gebber, S. W. Phillips, and S. M. Barman Role of the medullary lateral tegmental field in reflex-mediated sympathoexcitation in cats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R451 - R464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Madden and A. F. Sved Cardiovascular regulation after destruction of the C1 cell group of the rostral ventrolateral medulla in rats Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2734 - H2748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hayashi Exercise pressor reflex in decerebrate and anesthetized rats Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2026 - H2033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Wilson, D. Andrew, and A. D. Craig Activation of Spinobulbar Lamina I Neurons by Static Muscle Contraction J Neurophysiol, March 1, 2002; 87(3): 1641 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. LeDoux and L. B. Wilson Neuronal application of capsaicin modulates somatic pressor reflexes Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R868 - R877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Kramer, A. Aragones, and T. G. Waldrop Reflex cardiovascular responses originating in exercising muscles of mice J Appl Physiol, February 1, 2001; 90(2): 579 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. S. Possas, O. U. Lopes, and S. L. Cravo Glutamatergic and GABAergic inputs to the RVL mediate cardiovascular adjustments to noxious stimulation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R434 - R440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Natarajan and S. F. Morrison Sympathoexcitatory CVLM neurons mediate responses to caudal pressor area stimulation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R364 - R374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Schreihofer and P. G. Guyenet Sympathetic reflexes after depletion of bulbospinal catecholaminergic neurons with anti-Dbeta H-saporin Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R729 - R742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chau, D. G. Johns, and L. P. Schramm Ongoing and Stimulus-Evoked Activity of Sympathetically Correlated Neurons in the Intermediate Zone and Dorsal Horn of Acutely Spinalized Rats J Neurophysiol, May 1, 2000; 83(5): 2699 - 2707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tagawa and R. A. L. Dampney AT1 Receptors Mediate Excitatory Inputs to Rostral Ventrolateral Medulla Pressor Neurons From Hypothalamus Hypertension, December 1, 1999; 34(6): 1301 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Madden, S. Ito, L. Rinaman, R. G. Wiley, and A. F. Sved Lesions of the C1 catecholaminergic neurons of the ventrolateral medulla in rats using anti-Dbeta H-saporin Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R1063 - R1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Chao, L. L. Shen, S. Tjen-A-Looi, K. F. Pitsillides, P. Li, and J. C. Longhurst Naloxone reverses inhibitory effect of electroacupuncture on sympathetic cardiovascular reflex responses Am J Physiol Heart Circ Physiol, June 1, 1999; 276(6): H2127 - H2134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Hall, L. Wang, B. Milne, and C. Loomis Activation of the Rostral Ventrolateral Medulla in an Acute Anesthetized Rodent Strychnine Model of Allodynia Anesth. Analg., May 1, 1999; 88(5): 1125 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Caringi, D. J. Mokler, D. M. Koester, and A. Ally Rostral ventrolateral medullary opioid receptor activation modulates pressor response to muscle contraction Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H139 - H146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Feldman and J. J. Buccafusco Spinal Muscarinic, Glutamatergic and GABAergic Receptor Systems in Cardiovascular Regulation J. Pharmacol. Exp. Ther., April 1, 1997; 281(1): 274 - 283. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
