AJP - Regulatory, Integrative and Comparative Physiology, Vol 254, Issue 5 727-R729, Copyright © 1988 by American Physiological Society
Pentobarbital potentiates natriuretic response to acute volume expansion in monkeys
J. P. Gilmore, K. G. Cornish and M. W. Barazanji
Department of Physiology, University of Nebraska College of Medicine, Omaha 68105.
We determined the influence of pentobarbital sodium on the renal responses
of the monkey to acute intravascular volume expansion. Before volume
expansion, the anesthetized animals had a significantly lower blood
pressure and creatinine clearance and a significantly higher urine flow and
sodium excretion than the conscious animals. After volume expansion with an
isotonic, isoncotic, dextran solution, sodium excretion and urine flow
increased significantly in both groups of animals. However, both responses
were significantly greater in the anesthetized animals. The greater
natriuresis in the anesthetized animals was associated with a greater
fractional sodium excretion than in the conscious animals. The potentiated
response of the anesthetized animal may be the result of a direct renal
tubular effect of pentobarbital and/or the result of the anesthetic
removing an inhibitory influence on sodium excretion.
