AJP - Regulatory, Integrative and Comparative Physiology, Vol 253, Issue 3 444-R449, Copyright © 1987 by American Physiological Society

ARTICLES

Further evidence for hepatic control of salt intake in rats

M. G. Tordoff, J. Schulkin and M. I. Friedman

We examined the contributions of oral and hepatic factors to the control of salt intake in rats made "salt hungry" by combined dietary sodium restriction and furosemide treatment. A 7.5-ml preload of 0.5 M NaCl, which was either voluntarily ingested or slowly infused (7.5 ml/90 min) into the hepatic portal vein, decreased subsequent 0.5 M NaCl intake by approximately 7.5 ml in both cases. Hepatic portal infusions were probably acting in the liver because slow jugular infusions (7.5 ml/90 min) did not influence salt drinking, although rapid (7.5 ml/5 min) infusions by both routes reduced salt intake. If salt was ingested but drained through a gastric cannula, rats showed little sign of reducing salt in a 2-h test. These results suggest that the quantity of salt ingested by salt-hungry rats is regulated by a postabsorptive mechanism that is probably located in the liver.

This article has been cited by other articles:

				A. Godino, L. A. De Luca Jr., J. Antunes-Rodrigues, and L. Vivas Oxytocinergic and serotonergic systems involvement in sodium intake regulation: satiety or hypertonicity markers? Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1027 - R1036. [Abstract] [Full Text] [PDF]

				E. M. Stricker, M. A. Bushey, M. L. Hoffmann, M. McGhee, A. M. Cason, and J. C. Smith Inhibition of NaCl appetite when DOCA-treated rats drink saline Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R652 - R662. [Abstract] [Full Text] [PDF]

				E. M. Stricker, J. B. Callahan, W. Huang, and A. F. Sved Early osmoregulatory stimulation of neurohypophyseal hormone secretion and thirst after gastric NaCl loads Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1710 - R1717. [Abstract] [Full Text] [PDF]

				L. F. Franchini, A. K. Johnson, J. de Olmos, and L. Vivas Sodium appetite and Fos activation in serotonergic neurons Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R235 - R243. [Abstract] [Full Text] [PDF]

				M. G. Tordoff Calcium: Taste, Intake, and Appetite Physiol Rev, October 1, 2001; 81(4): 1567 - 1597. [Abstract] [Full Text] [PDF]

				M. G. Tordoff and S. A. McCaughey Influence of oral and gastric NaCl preloads on NaCl intake and gastric emptying of sodium-deficient rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1152 - R1160. [Abstract] [Full Text] [PDF]

				S. A. McCaughey and M. G. Tordoff Calcium deprivation alters gustatory-evoked activity in the rat nucleus of the solitary tract Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R971 - R978. [Abstract] [Full Text] [PDF]

				W. Huang, A. F. Sved, and E. M. Stricker Water ingestion provides an early signal inhibiting osmotically stimulated vasopressin secretion in rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R756 - R760. [Abstract] [Full Text] [PDF]

				W. Huang, A. F. Sved, and E. M. Stricker Vasopressin and oxytocin release evoked by NaCl loads are selectively blunted by area postrema lesions Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2000; 278(3): R732 - R740. [Abstract] [Full Text] [PDF]

				H. Morita, K. Tsunooka, M. Hagiike, O. Yamaguchi, and K. Lee Role of the liver in long-term control of drinking behavior, Na+ balance, and arterial pressure in Dahl rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R1111 - R1118. [Abstract] [Full Text] [PDF]

				M. G. Tordoff, R. L. Hughes, and D. M. Pilchak Calcium intake by rats: influence of parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R214 - R231. [Abstract] [Full Text] [PDF]