AJP - Regu Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 253: R8-R14, 1987;
0363-6119/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pratz, J.
Right arrow Articles by Corman, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pratz, J.
Right arrow Articles by Corman, B.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 253, Issue 1 8-14, Copyright © 1987 by American Physiological Society

ARTICLES

Cholesterol content and water and solute permeabilities of kidney membranes from aging rats

J. Pratz, P. Ripoche and B. Corman

The influence of the age-related increase in cholesterol content of kidney brush-border membranes on their water and solute permeabilities was studied in 10- and 24-mo-old male Wistar rats. These permeabilities were determined from the rate of shrinkage and swelling of brush-border vesicles using a stopped-flow apparatus coupled to a light transmission recording. Despite a 20% rise in total cholesterol per milligram proteins, the osmotic water permeabilities of the vesicles were unchanged between 10 (287 +/- 40 micron/s) and 24 mo (270 +/- 31 micron/s). In contrast, passive diffusions of NaCl and KCl, but not of urea, thiourea, and glycerol, were reduced by 35% between 10 and 24 mo. These results suggest that an increase in cholesterol content of kidney brush-border membrane decreases its salt permeabilities without altering the water pathways.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Preisser, L. Teillet, S. Aliotti, R. Gobin, V. Berthonaud, J. Chevalier, B. Corman, and J.-M. Verbavatz
Downregulation of aquaporin-2 and -3 in aging kidney is independent of V2 vasopressin receptor
Am J Physiol Renal Physiol, July 1, 2000; 279(1): F144 - F152.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online